Transcriptome analysis reveals the encystment-related lncRNA expression profile and coexpressed mRNAs in Pseudourostyla cristata.

Ciliated protozoans form dormant cysts for survival under adverse conditions. The molecular mechanisms regulating this process are critical for understanding how single-celled eukaryotes adapt to the environment. Despite the accumulated data on morphology and gene coding sequences, the molecular mechanism by which lncRNAs regulate ciliate encystment remains unknown.

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Cerebrospinal fluid (CSF) diversion or shunting procedures are the most commonly performed surgery for the treatment of hydrocephalus and are often employed in the management of elevated intracranial pressure due to a variety of diseases. Despite their popularity however, approximately 50% of shunts fail within the first two years, and several revisions are required within the first decade after placement. Ophthalmologists may encounter patients with a CSF shunt to evaluate for concerns of vision loss or diplopia and to determine if papilledema is present.

Cilia-assisted flow of viscoelastic fluid in a divergent channel under porosity effects.

Cilia-driven laminar flow of an incompressible viscoelastic fluid in a divergent channel has been conducted numerically using the BVP4C technique. The non-Newtonian Jeffrey rheological model is utilized to characterize the fluid. The flow equations are formulated in a curvilinear coordinate system, and the porosity effects are simulated with a body force term in the Navier-Stokes equation.

Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: Persicaria hydropiper (Smartweed).

Persicaria hydropiper (L.) Delarbre (family Polygonacea), commonly known as Polygonum hydropiper, is a popular medicinal plant used in traditional medicine. The plant is indigenous to the tropical northern hemisphere and temperate zone, including China, Bangladesh, India, and Japan.

Case Discussion and Literature Review: Cancer Immunotherapy, Severe Immune-Related Adverse Events, Multi-Inflammatory Syndrome, and Severe Acute Respiratory Syndrome Coronavirus 2.

Pediatric, adolescent and young adult (AYA) patients receiving novel cancer immunotherapies may develop associated toxicities with overlapping signs and symptoms that are not always easily distinguished from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection/clinical sequelae. We describe 2 diagnostically challenging cases of SARS-CoV-2 and Multi-Inflammatory Syndrome-Adult (MIS-A), in patients with a history of acute lymphoblastic leukemia following cellular therapy administration and review evolving characterization of both the natural course of SARS-CoV-2 infection and toxicities experienced in younger cancer immunotherapy patients. Vigilant monitoring for unique presentations and epidemiologic surveillance to promptly detect changes in incidence of either condition may be warranted.

Discordance Rate Among Bilateral Simultaneous and Sequential Temporal Artery Biopsies in Giant Cell Arteritis: Role of Frozen Sectioning Based on the Mayo Clinic Experience.

Importance: Frozen section temporal artery biopsy (TAB) may prevent a contralateral biopsy from being performed.

Objective: To evaluate the sensitivity and specificity of TAB frozen vs permanent section pathology results for giant cell arteritis (GCA) and determine the discordance rate of bilateral TABs.

Design, Setting, And Participants: In this retrospective cohort study, medical records were reviewed from 795 patients 40 years or older who underwent TAB from January 1, 2010, to December 1, 2018, treated at a single tertiary care center with the ability to perform both frozen and permanent histologic sections.

A Comparative Study of Salter Versus Pemberton Osteotomy in Open Reduction of Developmental Dysplastic Hips and Clinical Evaluation on Bhatti's Functional Score System.

Objective The study was aimed to compare the outcome of Salter's and Pemberton's osteotomy to achieve adequate acetabular coverage in the open reduction of developmental dysplastic hips (DDH). The functional outcome was evaluated as measured on Bhatti's Functional Score System (BFSS). Patients and methods The study includes 60 children with 82 hips of developmental dysplasia in walking-age children.

Evaluation of the Performance of Manual Antimicrobial Susceptibility Testing Methods and Disk Breakpoints for .

are an emerging cause of serious infections with high associated mortality in immunocompromised patients. Treatment of infections is complicated by intrinsic resistance to many antimicrobials, including carbapenems, aminoglycosides, and some cephalosporins. Despite this, >90% of isolates are susceptible to trimethoprim-sulfamethoxazole (SXT), which is front-line therapy for this organism.

Strategies for reducing greenhouse gas emissions from municipal solid waste management in Pakistan.

The studies on municipal solid waste (MSW) management in Pakistan and its impacts on greenhouse gas (GHG) emissions are glaringly missing. Therefore, this study examines the effect of MSW management on GHG emissions in Pakistan and suggests the best suitable strategies for alleviating GHG emissions. The Intergovernmental Panel on Climate Change (IPCC) 2006 waste model (WM) was used to create inventory of GHG emissions from landfilling.

Chemically Coupled Cobalt Oxide Nanosheets Decorated onto the Surface of Multiwall Carbon Nanotubes for Favorable Oxygen Evolution Reaction.

Cobalt oxide has been widely investigated among potential transition metal oxides for the electrochemical energy conversion, storage, and water splitting. However, they have inherently low electronic conductivity and high corrosive nature in alkaline media. Herein, we propose a promising and facile approach to improve the conductivity and charge transport of cobalt oxide Co₃O₄ through chemical coupling with well-dispersed multiwall carbon nanotubes (MWCNTs) during hydrothermal treatment.

TiO₂/ZnO Nanocomposite Material for Efficient Degradation of Methylene Blue.

In this research work, we have produced a composite material consisting titanium dioxide (TiO₂) and zinc oxide (ZnO) nanostructures via precipitation method. Scanning electron microscopy (SEM) study has shown the mixture of nanostructures consisting nanorods and nano flower. Energy dispersive spectroscopy (EDS) study has confirmed the presence of Ti, Zn and O as main elements in the composite.

Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein IgG associated disorder: A comprehensive neuro-ophthalmic review.

Neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated inflammatory disease of the central nervous system that involves the optic nerves, spinal cord, and often other specific brain regions such as area postrema of the medulla. NMOSD was formerly classified as a variant of multiple sclerosis (MS), given the similar symptomatology and relapsing course but is now considered to have distinct clinical, paraclinical, immunological and prognostic features. The discovery of aquaporin 4 (AQP4) immunoglobulin G (IgG) has improved the ability to diagnose NMOSD.

The Frequency of Carotid Intraplaque Hemorrhage on Vessel Wall Imaging in Patients With Retinal Artery Occlusion: A Cross-Sectional Prevalence Study.

Background: Intraplaque hemorrhage (IPH) in a carotid artery plaque viewed on vessel wall imaging has been shown to be associated with ischemic stroke. Whether such an association between carotid IPH and retinal artery occlusion (RAO) exists remains unknown.

Methods: This was a cross-sectional prevalence study.

Residual time of sinusoidal metachronal ciliary flow of non-Newtonian fluid through ciliated walls: fertilization and implantation.

The monitoring of the ciliated walls in the uterine tube has supreme importance in enhancing the sperm to reach the egg (capacitation processes), and at peristaltic ciliary flow has a more favorable residual time along the canal when compared to the peristaltic flow. Based on the importance of this study, a mathematical simulation of this process has been carried out by studying the behavior of a non-Newtonian magnetized fluid with a Darcy flow model with an oscillating wall having an internal ciliated surface. The governing equation is formed with Eyring-Powell fluid (tubal fallopian fluid) without using any approximations and solved using the Adomian analysis method.

A multi-center case series of sarcoid optic neuropathy.

Objective: The diagnosis of sarcoid optic neuropathy is time-sensitive, as delayed treatment risks irreversible vision loss. We sought to analyze its characteristics and outcomes.

Methods: We performed a multi-center retrospective study of sarcoid optic neuropathy among 5 USA medical centers.

Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disorder-optic neuritis: a comprehensive review of diagnosis and treatment.

Optic neuritis (ON) is the most common cause of acute optic neuropathy in patients younger than 50 years of age and is most frequently idiopathic or associated with multiple sclerosis. However, the discovery of aquaporin-4 immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG as biomarkers for two separate central nervous system inflammatory demyelinating diseases has revealed that neuromyelitis optica spectrum disorder (NMSOD) and MOG-IgG-associated disease (MOGAD) are responsible for clinically distinct subsets of ON. NMOSD-ON and MOGAD-ON both demonstrate tendencies for bilateral optic nerve involvement and often exhibit a relapsing course with the potential for devastating long-term visual outcomes.

Paediatric posterior fossa tumour resection rates in a small volume centre: the past decade's experience.

Background: Paediatric brain tumour resection rates have been shown to correlate with outcome and, it is argued, are linked to operator volume and caseload. The British paediatric neurosurgery community has previously debated centralisation of paediatric neuro-oncology. At the 2018 British Paediatric Neurosurgery Group (BPNG) meeting, a commitment was made to prospectively collect tumour resection data at each Neurosurgical Unit (NSU).

Entropy Analysis on the Blood Flow through Anisotropically Tapered Arteries Filled with Magnetic Zinc-Oxide (ZnO) Nanoparticles.

The present analysis deals with the entropy analysis of the blood flow through an anisotropically tapered arteries under the suspension of magnetic Zinc-oxide (ZnO) nanoparticles (NPs). The Jeffrey fluid model is contemplated as blood that is electrically conducting and incompressible. The lubrication approach is used for the mathematical modeling.

Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder.

Background: The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated.

Objective And Methods: We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD.

Results: White-blood-cell (>5/mm) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.

Impact of metallic nanoparticles on anaerobic digestion: A systematic review.

Anaerobic digestion (AD) is one of the most energy-efficient waste treatment technologies for biodegradable wastes. Owing to the increasing trend of metallic nanoparticle applications in industry, they are ubiquitous to the waste streams, which may lead to remarkable impacts on the performance of the AD process. This review addresses the knowledge gaps and summarises the findings from the academic articles published from 2010 to 2019 focusing on the influences on both AD processes of biochemical hydrogen-generation and methane-production from selected metallic nano-materials.