Thresholds for Spinal Anaesthesia-induced Hypotension During Caesarean Section.

Background Spinal anaesthesia is the current standard for caesarean section. Hypotension, a common complication, potentially results in adverse foetal and maternal outcomes. However, hypotension-defining criteria are varied.

Crystal structure and Hirshfeld surface analysis of 2,2,2-tri-chloro-,-bis-{[(1,4)-1,4-di-hydro-1,4-ep-oxy-naphthalen-1-yl]meth-yl}acetamide.

In the title compound, CHClNO, the tetra-hydro-furan rings adopt envelope conformations. In the crystal, C-H⋯O hydrogen bonds connect mol-ecules, generating layers parallel to the (001) plane. These layers are connected along the axis direction by C-H⋯π inter-actions.

Crystal structure and Hirshfeld surface analysis of ()-1-[2,2-di-chloro-1-(4-methyl-phen-yl)ethen-yl]-2-(4-meth-oxy-phen-yl)diazene.

The asymmetric unit of the title compound, CHClNO, comprises two similar mol-ecules, and , in which the dihedral angles between the two aromatic rings are 70.1 (3) and 73.2 (2)°, respectively.

Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?

Background: Extensive literature has shown an association of Adverse Childhood Experiences (ACEs) with adverse health outcomes; however, its ability to predict events or stratify risks is less known. Individuals with mental illness and ACE exposure have been shown to visit emergency departments (ED) more often than those in the general population. This study thus examined the ability of the ACEs checklist to predict ED visits within the subsequent year among children and adolescents presenting to mental health clinics with pre-existing mental health issues.

Crystal structure and Hirshfeld surface analysis of dimethyl 5-[2-(2,4,6-trioxo-1,3-diazinan-5-yl-idene)hydrazin-1-yl]benzene-1,3-di-carboxyl-ate 0.224-hydrate.

In the crystal, the whole mol-ecule of the title compound, CHNO·0.224HO, is nearly planar with a maximum deviation from the least-squares plane of 0.352 (1) Å.

Febrile Seizure in Children Attending a Tertiary Care Centre in Western Nepal: A Descriptive Cross-sectional Study.

Introduction: Understanding a child with any episode of febrile seizure is important so that special attention could be given. The objective of this study was to find the prevalence of febrile seizure in children attending a tertiary centre in western Nepal.

Methods: A descriptive cross-sectional study was performed in a tertiary care centre at the department of Pediatrics after taking approval from the Institutional Review Committee.

Self-medication in Primary Dysmenorrhea among Medical and Nursing Undergraduate Students of a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

Introduction: Primary dysmenorrhea is one of the most common gynecological problems among adolescent females. It is defined as painful menses in women with normal pelvic anatomy, usually beginning during adolescence. This study aims to find out prevalence of self-medication practice in primary dysmenorrhea among medical and nursing undergraduate students.

Use of Statins as Lipid Lowering Agent in Hypercholesterolemia in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

Introduction: Lipids contribute to atherosclerosis and obesity that can lead to different cardiovascular diseases. Statins are hydroxymethylglutaryl reductase inhibitors that effectively lower the cholesterol level. It is widely prescribed in the treatment of hypercholesterolemia.

Information about COVID-19 among Selected Population of Eastern Nepal: A Descriptive Cross-sectional Study.

Introduction: Rapid spread of COVID-19 has become a major concern worldwide. Strong adherence to preventive measures can help to break the chain of the spread of coronavirus. We conducted this study to find out the extent of information general people of Eastern Nepal have regarding COVID-19 and their attitude and practice towards preventing its spread.

Positive allosteric mechanisms of adenosine A receptor-mediated analgesia.

The adenosine A receptor (AR) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain. However, development of analgesic orthosteric AR agonists has failed because of a lack of sufficient on-target selectivity as well as off-tissue adverse effects. Here we show that [2-amino-4-(3,5-bis(trifluoromethyl)phenyl)thiophen-3-yl)(4-chlorophenyl)methanone] (MIPS521), a positive allosteric modulator of the AR, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain.

Crystal structure and Hirshfeld surface analysis of 1,3-bis-{2,2-di-chloro-1-[()-phenyl-diazen-yl]ethen-yl}benzene.

In the mol-ecule of the title compound, CHClN, the central benzene ring makes dihedral angles of 77.03 (9) and 81.42 (9)° with the two approximately planar 2,2-di-chloro-1-[()-phenyl-diazen-yl]vinyl groups.

A literature review on large intestinal hyperelastic constitutive modeling.

Impacts, traumas and strokes are spontaneously life-threatening, but chronic symptoms strangle patient every day. Colorectal tissue mechanics in such chronic situations not only regulates the physio-psychological well-being of the patient, but also confirms the level of comfort and post-operative clinical outcomes. Numerous uniaxial and multiaxial tensile experiments on healthy and affected samples have evidenced significant differences in tissue mechanical behavior and strong colorectal anisotropy across each layer in thickness direction and along the length.

Clinical Profile and Diagnosis of Obstructive Sleep Apnea Syndrome using Overnight Polysomnography in a Tertiary Care Hospital.

Background Obstructive sleep apnea is a highly prevalent yet largely under-diagnosed disease that poses a significant burden on the healthcare system. Objective To determine the role of predictors for Obstructive sleep apnea syndrome and its severity in Nepalese population. Method Prospective and analytical study conducted in the Department of Otorhinolaryngology and Head and Neck surgery at Kathmandu University Hospital between March 2018 and June 2020.

Mechanism of Ligand Recognition by Human ACE2 Receptor.

Angiotensin converting enzyme 2 (ACE2) plays a key role in renin-angiotensin system regulation and amino acid homeostasis. Human ACE2 acts as the receptor for severe acute respiratory syndrome coronaviruses SARS-CoV and SARS-CoV-2. ACE2 is also widely expressed in epithelial cells of the lungs, heart, kidney, and pancreas.

Association of cucurbit aphid-borne yellows virus with cucumber plants in India.

Unlabelled: Symptoms like bright yellowing, puckering of the leaf, vein banding, and vein thickening were observed on different cucurbit hosts at the experimental farm of Indian Agricultural Research Institute, New Delhi during 2019. Leaf-dip electron microscopy of the symptomatic leaves revealed the association of isometric virus particles measuring ~ 25 nm with bitter gourd and cucumber samples. The RT-PCR assay using polerovirus generic primers covering the partial RdRp, intergenic region, and partial CP region was resulted the amplicons of ~ 1.

Crystal structure and Hirshfeld surface analysis of ()-3-hy-droxy-2-{[(3a,6,7a)-2-(4-methyl-phenyl-sulfon-yl)-2,3,3a,6,7,7a-hexa-hydro-3a,6-ep-oxy-1-isoindol-6-yl]meth-yl}isoindolin-1-one.

The title compound, CHNOS, crystallizes with two independent mol-ecules ( and ) in the asymmetric unit. In the central ring systems of both mol-ecules, the tetra-hydro-furan rings adopt envelope conformations, the pyrrolidine rings adopt a twisted-envelope conformation and the six-membered ring is in a boat conformation. In mol-ecules and , the nine-membered groups attached to the central ring system are essentially planar (r.

COVID-19 Case Surveillance: Trends in Person-Level Case Data Completeness, United States, April 5-September 30, 2020.

Objectives: To obtain timely and detailed data on COVID-19 cases in the United States, the Centers for Disease Control and Prevention (CDC) uses 2 data sources: (1) aggregate counts for daily situational awareness and (2) person-level data for each case (case surveillance). The objective of this study was to describe the sensitivity of case ascertainment and the completeness of person-level data received by CDC through national COVID-19 case surveillance.

Methods: We compared case and death counts from case surveillance data with aggregate counts received by CDC during April 5-September 30, 2020.

UV-Vis studies of methyl red in the presence of sodium dioctylsulfosuccinate/acetone and sodium dioctylsulfosuccinate/acetone/water.

This paper reports the spectra of methyl red (MR) in the presence of sodium dioctylsulfosuccinate (AOT) by UV-Vis spectrophotometer at 298.15 ± 0.1 K.

Exploring the conformational dynamics and flexibility of intrinsically disordered HIV-1 Nef protein using molecular dynamic network approaches.

Unlabelled: Intrinsically disordered proteins represent a class of proteins that lack fixed and well-defined three-dimensional structures in solution. HIV-1 Nef is an intrinsically disordered peripheral membrane protein involved in the replication and pathogenesis of HIV-1 infection. Nef controls expression levels of cell surface CD4 molecules that are essential for adaptive immunity.

Extract of ( Miller) Enhances the Growth, Protein Contents, and Gastrosomatic Index (GaSI) of Common Carp .

Aquaculture is a growing agribusiness, and large-scale microbial infection frequently leads to considerable economic losses, as there are very few approved drugs available to counteract such a problem. is a natural therapeutic plant with biological activities, for example, antimicrobial, anticancer, mitigating, and immunomodulatory properties. Thus, an experiment was conducted to understand the effects of dietary on survival, growth performance, protein utilization, gastrosomatic index, and gut histomorphological studies in common carp in laboratory conditions.

Garlic-induced face burn.

There is inadequate research and study into the use of garlic and other herbal medicine in clinical practice; accordingly, the general population should be cautious when using such complementary and herbal treatments. We report a case which highlights the potential complications following the application of garlic-related naturopathic remedies mostly on skin burns.

Thermodynamic Properties of Cetyltrimethylammonium Bromide in Ethanol-Water Media With/without the Presence of the Divalent Salt.

The physicochemical properties of cetyltrimethylammonium bromide (CTAB) in pure water and ethanol-water mixtures in the presence and absence of MnSO.6HO were studied by measuring the conductivity at room temperature. The concentration range of CTAB was ~1.

Crystal structure and Hirshfeld surface analysis of ethyl (4,4a)-2-methyl-5,8-dioxo-6-phenyl-4a,5,6,7,7a,8-hexa-hydro-4-furo[2,3-]iso-indole-4-carboxyl-ate.

In the title compound, CHNO, the central six-membered ring has a slightly distorted half-chair conformation, with puckering parameters of = 0.3387 (11) Å, θ = 49.11 (19)° and φ = 167.