Impact of dizziness and obesity on the prevalence of falls and fall-related injuries.

Objectives/hypothesis: Quantify the relationships between dizziness, falls, and obesity among adults.

Study Design: Cross-sectional analysis of a national health survey.

Methods: Adult respondents in the 2008 National Health Interview Survey balance module were analyzed.

Incremental and comparative health care expenditures for head and neck cancer in the United States.

Objectives/hypothesis: Determine the incremental costs associated with head and neck cancer (HNCa) and compare the costs with other common cancers.

Study Design: Cross-sectional analysis of a healthcare expenditure database.

Methods: The Medical Expenditure Panel Survey is a national survey of US households.

Revisit rates and diagnoses following pediatric tonsillectomy in a large multistate population.

Objectives/hypothesis: Investigate the incidence and characteristics of revisits following ambulatory pediatric tonsillectomy/adenotonsillectomy.

Study Design: Cross-sectional study using national databases.

Methods: Ambulatory pediatric (age <18.

The prevalence of voice problems among adults in the United States.

Objectives/hypothesis: Determine the prevalence of voice problems and types of voice disorders among adults in the United States.

Study Design: Cross-sectional analysis of a national health survey.

Methods: The 2012 National Health Interview Survey was analyzed, identifying adult cases reporting a voice problem in the preceding 12 months.

Identification of an endoplasmic reticulum membrane protein interacting with DNA polymerase beta by a yeast two-hybrid screen.

Base excision repair (BER) is a key pathway for maintaining genomic stability. A key enzyme in the BER pathway is DNA polymerase beta (polbeta). It has been shown that more than 11% of breast, bladder, esophageal, colon, and gastric cancer samples studied so far exhibit polbeta mutation.

Revisits and readmissions following ambulatory uvulopalatopharyngoplasty.

Objectives/hypothesis: Determine rates and reasons for revisits after adult uvulopalatopharyngoplasty (UPPP).

Study Design: Cross-sectional analysis of multistate ambulatory surgery and hospital databases.

Methods: Ambulatory adult UPPP cases were extracted from the State Ambulatory Surgery Databases for New York, Florida, Iowa, and California for 2010.

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

Mis-sense mutations in the α-subunit of the G-protein, Gsα, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active Gsα and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the identification of small molecule inhibitors specific for the mutant Gsα protein, the so-called gsp oncogene.

MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes.

MicroRNA (miRNA) regulates expression of protein coding genes and has been implicated in diverse cellular processes including neuronal differentiation, cell growth and death. To identify the role of miRNA in neuronal differentiation, SH-SY5Y and IMR-32 cells were treated with dopamine cocktail and retinoic acid to induce differentiation. Detection of miRNAs in differentiated cells revealed that expression of many miRNAs was altered significantly.

Regional variation and factors associated with image guidance utilization during endoscopic sinus surgery in the ambulatory setting.

Objective: Determine regional variation and factors associated with the use of image guidance (IG) during endoscopic sinus surgery (ESS) in the ambulatory surgery center setting.

Methods: All cases of ESS in 2010 were extracted from the state ambulatory surgery databases for New York, North Carolina, Florida, Iowa, and California. Current Procedural Terminology codes for individual sinusotomies and IG and International Classification of Diseases codes along with insurance and regional data were analyzed to determine factors that were associated with the use of IG during ESS.

Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease.

Background: A large percentage of patients with aspirin exacerbated respiratory disease (AERD) report the development of alcohol-induced respiratory reactions, but the true prevalence of respiratory reactions caused by alcoholic beverages in these patients was not known.

Objective: We sought to evaluate the incidence and characteristics of alcohol-induced respiratory reactions in patients with AERD.

Methods: A questionnaire designed to assess alcohol-induced respiratory symptoms was administered to patients at Brigham and Women's Hospital and Scripps Clinic.

Universality splitting in distribution of number of miRNA co-targets.

In a recent work (Basu et al., in EPL 105:28007, 2014) it was pointed out that the link-weight distribution of microRNA co-target network of a wide class of species are universal up to scaling. The number cell types, widely accepted as a measure of complexity, turns out to be proportional to these scale-factor.

Transcription regulation of HYPK by Heat Shock Factor 1.

HYPK (Huntingtin Yeast Partner K) was originally identified by yeast two-hybrid assay as an interactor of Huntingtin, the protein mutated in Huntington's disease. HYPK was characterized earlier as an intrinsically unstructured protein having chaperone-like activity in vitro and in vivo. HYPK has the ability of reducing rate of aggregate formation and subsequent toxicity caused by mutant Huntingtin.

Unplanned revisits and readmissions after ambulatory sinonasal surgery.

Objectives/hypothesis: Determine rates and reasons for revisits after adult ambulatory sinonasal surgery.

Study Design: Cross-sectional analysis of multi-state ambulatory surgery and hospital databases.

Methods: Ambulatory adult sinonasal procedures were extracted from the State Ambulatory Surgery Databases for New York, Florida, Iowa, and California for 2010.

Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes.

Calcium and phosphorus homeostasis is achieved by interplay among hormones, including 1,25(OH)2D3 (1,25D), parathyroid hormone, and fibroblast growth factor 23 (FGF23), and their interactions with other proteins. For example, mutations in dentin matrix protein 1 (DMP-1) result in increased FGF23 and hypophosphatemic rickets. 1,25D is reported to modulate FGF23; thus, we hypothesized that 1,25D may be involved in modulating DMP-1 in an intermediary step.

Revisits and postoperative hemorrhage after adult tonsillectomy.

Objectives/hypothesis: Determine revisits and reasons for revisits after adult tonsillectomy.

Study Design: Cross-sectional analysis of multistate ambulatory surgery and hospital databases.

Methods: Ambulatory adult tonsillectomies performed as the sole procedure were extracted from the State Ambulatory Surgery databases for New York, Florida, Iowa, and California for 2010.

Medications prescribed at ambulatory visits for nasal polyposis.

Background: Nasal polyps occur in a significant fraction of patients with chronic rhinosinusitis. However, patterns of medical management in nasal polyp cases are unknown. We sought to determine actual national estimates and contemporary prescribing patterns for ambulatory care visits with a diagnosis of nasal polyposis (NP).

Signal Transduction Pathways Mediated by Secreted and Non-secreted Forms of intact Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) and its 1-97 N-terminal Fragment in PC-3 Human Prostate Cancer Cells.

Our previous results indicated that both the secreted and the intracellular form of full length and 1-97 N-terminal fragment of IGFBP-3 induces apoptosis in PC-3 human prostate cancer cells in an IGF-dependent and independent manner. This study was undertaken to delineate possible down-stream signaling pathways that are involved in this process. Intact IGFBP-3 and its N-terminal 1-97 fragments with or without a signal pro-peptide was fused to YFP and expressed in PC-3 human prostate cancer cells.

A comparative study of Hasford score and Sokal index in prognostication of the novo chronic myeloid leukemia patients and a search for new prognostic markers.

Introduction: Chronic myeloid leukemia (CML) is a common myeloproliferative disorder. Based on clinical and hematological parameters, two prognostic scoring systems, i.e.

Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin.

Growth factor receptor protein binding protein 2 (Grb2) is known to be associated with intracellular growth and proliferation related signaling cascades. Huntingtin (Htt), a ubiquitously expressed protein, when mutated, forms toxic intracellular aggregates - the hallmark of Huntington's disease (HD). We observed an elevated expression of Grb2 in neuronal cells in animal and cell models of HD.

Combined changing patterns of hospital utilization for head and neck cancer care: implications for future care.

Importance: The care of patients with head and neck cancer is labor and cost intensive. Although several studies have focused on clinical outcomes with regionalization of care of such patients, it remains uncertain if and where such concentrations of care are occurring. A better understanding of how care is distributed will improve our understanding of the financial and educational impact of compacting treatment of these patients.

Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia.

Pathologically elevated serum levels of fibroblast growth factor-23 (FGF23), a bone-derived hormone that regulates phosphorus homeostasis, result in renal phosphate wasting and lead to rickets or osteomalacia. Rarely, elevated serum FGF23 levels are found in association with mosaic cutaneous disorders that affect large proportions of the skin and appear in patterns corresponding to the migration of ectodermal progenitors. The cause and source of elevated serum FGF23 is unknown.

Primary squamous cell carcinoma with mucormycosis in a diabetic foot ulcer.

The diabetic foot ulcer is one of the major complications of diabetes mellitus leading to prolonged hospital stay. Non-healing foot ulcers in diabetes may be due to peripheral neuropathy and/or vasculopathy. Non-healing occurs following a trivial trauma due to loss of local immunity and increased infection by bacteria and fungus.

Obesity and the risk of chronic rhinosinusitis, allergic rhinitis, and acute otitis media in school-age children.

Objectives/hypothesis: To determine if obesity is a significant risk factor for acute otitis media (AOM), allergic rhinitis (AR), or chronic rhinosinusitis (CRS) in children and to understand the potential otolaryngological implications of childhood obesity.

Study Design: Cross-Sectional Analysis.

Methods: The 2006 and 2008 the Medical Expenditure Panel Survey was utilized to identify school-aged children with AOM, AR, and/or CRS.

MicroRNA-124 targets CCNA2 and regulates cell cycle in STHdh(Q111)/Hdh(Q111) cells.

Mutation in huntingtin (HTT) gene causes Huntington's disease (HD). Expression of many micro RNAs is known to alter in cell, animal models and brains of HD patients, but their cellular effects are not known. Here, we show that expression of microRNA-124 (miR-124) is down regulated in HD striatal mutant STHdh(Q111)/Hdh(Q111) cells, a cell model of HD compared to STHdh(Q7)/Hdh(Q7) cells.