Whole-Heart Histological and CMR Validation of Electroanatomic Mapping by Multielectrode Catheters in an Ovine Model.

Background: Accurate electroanatomic mapping is critical for identifying scar and the long-term success of ventricular tachycardia ablation.

Objectives: This study sought to determine the accuracy of multielectrode mapping (MEM) catheters to identify scar on cardiac magnetic resonance (CMR) and histopathology.

Methods: In an ovine model of myocardial infarction, we examined the effect of electrode size, spacing, and mapping rhythm on scar identification compared to CMR and histopathology using 5 multielectrode mapping catheters.

Extracorporeal Membrane Oxygenation for Patients With Electrical Storm or Refractory Ventricular Arrhythmias: Management and Outcomes.

Patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) are at high risk for ventricular arrhythmias due to derangements in myocardial perfusion, hemodynamics, and heightened catecholamine states. Existing data on the management and outcomes of patients with electrical storm or refractory ventricular tachycardia/fibrillation (VT/VF) treated with VA-ECMO are primarily derived from retrospective observational studies. Typical survival rates are in the range of 40%-50%, with 15%-20% of patients undergoing VT ablation and 30%-40% of patients requiring advanced heart failure therapies (cardiac transplant or durable left ventricular assist device).

Yield of Coronary Assessment in Sustained Monomorphic Ventricular Tachycardia.

Background: Coronary assessment is frequently conducted in patients with sustained monomorphic ventricular tachycardia (SMVT); however, its yield and subsequent treatment implications remain unclear. This study aimed to determine the prevalence of coronary artery disease (CAD) in patients presenting with SMVT, factors influencing clinician referral for coronary assessment, and clinical outcomes based on revascularisation or medical management of CAD.

Method: Consecutive patients presenting with acute SMVT requiring inpatient admission between 2017 and 2022 were identified.

Canard explosions in turbulent thermo-fluid systems.

A sudden transition to a state of high-amplitude periodic oscillations is catastrophic in a thermo-fluid system. Conventionally, upon varying the control parameter, a sudden transition is observed as an abrupt jump in the amplitude of the fluctuations in these systems. In contrast, we present an experimental discovery of a canard explosion in a turbulent reactive flow system where we observe a continuous bifurcation with a rapid rise in the amplitude of the fluctuations within a narrow range of control parameters.

Cu-doped LaNiO perovskite catalyst for DRM: revisiting it as a molecular-level nanocomposite.

Dry reforming of methane (DRM) was extensively studied on Cu-doped LaNiO catalysts. The main findings of this work are as follows: (i) thermal switching of the catalyst phase between the parent perovskite and molecular-level nanocomposite of individual components formed during DRM, (ii) reusability of the catalyst with enhanced activity, and (iii) regeneration of the catalyst phase at a lower temperature than that required for the formation of the parent perovskite. The present investigation provides an extensive analysis and understanding of the DRM reaction using Cu-doped LaNiO compared to the result reported by Moradi , (, 2012, , 797-801) and hence provides new insights into its catalytic activity.

Spontaneous termination of ventricular tachycardia in the human heart.

Introduction: Understanding the spatiotemporal location of the spontaneous termination of ventricular tachycardia (VT) may provide new insights for ablation. To test the hypothesis that spontaneous VT termination most frequently occurs at the VT exit due to source-sink mismatch and to characterize electrophysiological properties of the sites termination during VT and with extra-stimulus technique.

Methods: Retrospective analysis of intraoperative mapping studies of nine patients with ischemic cardiopathy or repaired tetralogy of Fallot.

Evolution of Substrate for Ventricular Arrhythmias Early Postinfarction: Insights From a Porcine Ischemia-Reperfusion Model.

Background: The evolution of myocardial scar and its arrhythmogenic potential postinfarct is incompletely understood.

Objectives: This study sought to investigate scar and border zone (BZ) channels evolution in an animal ischemia-reperfusion injury model using late gadolinium enhancement cardiac magnetic resonance (LGE-CMR).

Methods: Five swine underwent 90-minute balloon occlusion of the mid-left anterior descending artery, followed by LGE-CMR at day (d) 3, d30, and d58 postinfarct.

Elasto-compliance of harmonically stimulated soft micro-gaps during electro-magneto-kinetic flows.

In this article, we develop and solve an analytical model to understand the elasto-hydrodynamic force response of a deformable, soft substrate, under dynamic loading; wherein the microfluidic gap between the substrate and load is subjected to electro-magneto-hydrodynamic interactions. As a simple physical system, we model the coupled fluid-structure-interaction characteristics when a rigid, small cylinder is permitted to impinge harmonically on an infinitely large elastic, soft substrate, and an oscillatory, squeeze flow establishes in the micro-gap formed between the two. We discuss the different observations and mechanics in terms of the governing Dukhin, Hartmann, and electroviscous numbers.

Integrated CO Capture and Dry Reforming of CH to Syngas: A Review.

Integrating carbon capture with dry reforming of methane offers a promising approach to addressing greenhouse gas emissions while producing valuable syngas. This review examines the complexities and progress made in this integrated process, wherein catalysts play a critical role in adsorbing carbon dioxide and facilitating the conversion of methane to syngas. The chemical process entails the concurrent capture of CO emissions and their usage in dry reforming, a reaction in which CH interacts with CO to generate syngas, an essential precursor for various industrial applications.

Pathological Fracture of the Femur Following Chronic Osteomyelitis: A Case Report of This Rare Presentation in Adults.

Chronic osteomyelitis is a common presentation in orthopaedics, particularly in the context of deep abscesses. Fractures related to osteomyelitis can be seen in children but are rare in adults. We present the rare case of a pathological fracture related to osteomyelitis in a 53-year-old warehouse worker who was previously fit and well.

The Current Landscape of Ventricular Tachycardia Trials: A Systematic Review of Registered Studies.

Background: Although there are evolving techniques and technologies for treating ventricular tachycardia (VT), the current landscape of clinical trials for managing VT remains understudied.

Objective: The objective of this study was to provide a systematic characterisation of the interventional management of VT through an analysis of the ClinicalTrials.gov, clinicaltrialsregister.

Hybrid Metal Oxide (Ag-ZnO) Impregnated Biocomposite in the Development of an Eco-Friendly Sustainable Film.

Nanotechnology offers an innovative application as an eco-friendly food packaging film fabricated along with a degradable active mixture (AM). The AM is an assortment of alloyed metal oxide nanoparticles (Ag-ZnO), citron powder (AA), and Curcuma peel powder (CPP). Alloyed nanoparticles (NPs) were observed to exhibit a hexagonal structure from the experimental X-ray diffraction.

Venous Congestion Assessed by Venous Excess Ultrasound (VExUS) and Acute Kidney Injury in Children with Right Ventricular Dysfunction.

Background: Right ventricular dysfunction (RVD) is a complication following congenital cardiac surgery in children and can lead to systemic venous congestion, low cardiac output, and organ dysfunction. Venous congestion can be transmitted backwards and adversely affect encapsulated organs such as the kidneys.

Primary Objective: To investigate the association between systemic venous congestion, as estimated by Venous Excess Ultrasound (VExUS), and the occurrence of acute kidney injury (AKI) in children with RVD following congenital heart surgery.

Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1 mouse model of autism.

Excessive neural variability of sensory responses is a hallmark of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms but unknown neurobiological substrate. Here, by recording neocortical single neuron activity in a well-established mouse model of Fragile X syndrome and autism, we characterized atypical sensory processing and probed the role of endogenous noise sources in exaggerated response variability in males. The analysis of sensory stimulus evoked activity and spontaneous dynamics, as well as neuronal features, reveals a complex cellular and network phenotype.

Technological solutions for NO, SO, and VOC abatement: recent breakthroughs and future directions.

NO, SO, and carbonaceous volatile organic compounds (VOCs) are extremely harmful to the environment, and their concentrations must be within the limits prescribed by the region-specific pollution control boards. Thus, NO, SO, and VOC abatement is essential to safeguard the environment. Considering the importance of NO, SO, and VOC abatement, the discussion on selective catalytic reduction, oxidation, redox methods, and adsorption using noble metal and non-noble metal-based catalytic approaches were elaborated.

Mortality after catheter ablation of structural heart disease related ventricular tachycardia.

Background: There is a paucity of data describing mortality after catheter ablation of ventricular tachycardia (VT).

Objectives: We describe the causes and predictors of cardiac transplant and/or mortality following catheter ablation of structural heart disease (SHD) related VT.

Methods: Over 10-years, 175 SHD patients underwent VT ablation.

Utility of Substrate Mapping Using Extrasystole to Localise Comprehensive Ventricular Tachycardia Circuits: Results From Intra-operative Mapping Studies.

Background: Substrate mapping-based identification of all ventricular tachycardia (VT) circuits (diastolic activation), including partial and complete diastolic circuits in clinical and nonclinical VT, could be beneficial in guiding VT ablation to prevent VT recurrence. The utility of extrasystole induced late potentials has not been compared with late potentials in sinus rhythm (SR) and right ventricular pacing (RVp).

Methods: Intraoperative simultaneous panoramic endocardial mapping of 21 VTs in 16 ischemic heart disease patients was performed with the use of a 112-bipole endocardial balloon.

Study of retinal nerve fiber layer thickness in diabetic patients using optical coherence tomography.

Purpose: This study aimed to assess and compare the changes in peripapillary retinal nerve fiber layer (RNFL) thickness in nondiabetics and diabetics with various stages of diabetic retinopathy (DR).

Methods: The study subjects were divided into four groups based on their diabetic status and findings, namely, controls (normal subjects without diabetes [NDM]), diabetics without retinopathy (NDR), nonproliferative DR (NPDR), and proliferative DR (PDR). Peripapillary RNFL thickness was assessed using optical coherence tomography.