Publications by authors named "Bharti Rakhecha"
Abnormal epigenetics has been recognised as an early event in tumour progression and aberrant acetylation of lysine in particular has been understood in tumorigenesis. Therefore, it has become an attractive target for anticancer drug development. However, HDAC inhibitors have limited success due to toxicity and drug resistance concerns.
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- Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, with tumor necrosis factor α (TNF-α) playing a key role in promoting this inflammation; nicotine was investigated for its potential anti-inflammatory effects against RA.
- The study involved extracting and purifying nicotine from Brassica oleracea, using high-performance liquid chromatography (HPLC), and employing in-silico methods to assess nicotine’s drug-likeness before conducting in-vitro tests on TNFα-induced SW982 synoviocytes.
- Results showed that nicotine significantly reduced the expression of various pro-inflammatory cytokines and proteins in these cells, suggesting that it could be a viable natural treatment for RA over synthetic alternatives.