Publications by authors named "Bharti Kumari"

With regard to underground hydrogen storage projects, presuming that the hydrogen storage site has served as a repository for methane, the coexistence of a blend of methane and hydrogen is anticipated during the incipient stage of hydrogen storage. Therefore, the solubility of hydrogen/methane mixtures in brine becomes imperative. On the contrary, laboratory tasks of such measurements are hard because of its extreme corrosion ability and flammability, hence modeling methodologies are highly preferred.

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Background: Inflammation has an important role in the progression of endometrial carcinoma.

Aims: The aim of this study is to find the association between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and CA125 in endometrial hyperplasia and endometrial carcinoma. The study also focuses on the association of CA125, NLR, and PLR with histopathological parameters in endometrial carcinoma that are of prognostic importance.

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Background: Delirium is a common complication in hospitalized older adults with multifactorial etiology and poor health outcomes.

Aim: To determine the frequency and predictors of delirium and its short-term and long-term outcomes in hospitalized older adults.

Methods: A prospective observational study was performed in patients aged ≥60 years consecutively admitted to geriatric ward.

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Round cell tumors are a group of malignant tumors which shows overlapping microscopic features of small round monotonous cells with hyper-chromatic nucleus. It mostly occurs in children, adolescent, and young adults. The ancillary technique to confirm the differential diagnosis of round cells sarcoma is immuno-histo chemistry (IHC).

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Dirhodium(II) complexes such as [Rh(TFA)] bound to a functionalized mesoporous SBA-15 carrier material have proven to be valuable candidates for heterogeneous catalysis in the field of pharmaceutical synthesis. However, the mechanistic steps of immobilization by linker molecules containing carboxyl or amine functionalities remain the subject of discussion. Here we present a theoretical study of possible mechanistic binding pathways for the [Rh(TFA)] complex through model representations of synthetically investigated linkers, namely -butylamine and -butyric acid.

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The structure and surface functionalization of biologically relevant silica-based hybrid materials was investigated by 2D solid-state NMR techniques combined with dynamic nuclear polarization (DNP). This approach was applied to a model system of mesoporous silica, which was modified through in-pore grafting of small peptides by solid-phase peptide synthesis (SPPS). To prove the covalent binding of the peptides on the surface, DNP-enhanced solid-state NMR was used for the detection of N NMR signals in natural abundance.

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Article Synopsis
  • MicroRNAs (miRNAs) like let-7a and let-7b are released from activated microglia during Japanese Encephalitis virus (JEV) infection and may worsen neuronal damage.
  • Let-7a/b influences inflammation in microglial cells via the TLR7 signaling pathway, and their role in JEV's harmful effects was investigated, revealing a suppression of cytokine production with TLR7 knockdown.
  • The exosomes from let-7a/b-overexpressing microglia lead to caspase activation in healthy neurons, contributing to neuronal death and highlighting the complex role of these miRNAs in JEV pathogenesis.
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Artificial microRNA (amiRNA)-mediated inhibition of viral replication has recently gained importance as a strategy for antiviral therapy. In this study, we evaluated the benefit of using the amiRNA vector against Japanese encephalitis virus (JEV). We designed three single amiRNA sequences against the consensus sequence of 3' untranslated region (3'UTR) of JEV and tested their efficacy against cell culture-grown JEV Vellore strain (P20778) in neuronal cells.

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Changes in circulating microRNAs (miRNAs) in the cerebrospinal fluid (CSF) have been associated with different neurological diseases. Here, we presented results of a pilot study aimed at determining the feasibility of detecting miRNAs in the CSF of Japanese Encephalitis virus (JEV) infected individuals with acute encephalitis syndrome (AES). We demonstrated the circulating miRNA profile in CSF of acute encephalitis patients infected with JEV.

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Microglia cells in the brain play essential role during Japanese Encephalitis Virus (JEV) infection and may lead to change in microRNA (miRNA) and mRNA profile. These changes may together control disease outcome. Using Affymetrix microarray platform, we profiled cellular miRNA and mRNA expression at multiple time points during viral infection in human microglial (CHME3) cells.

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Background: Microglial cells, which are resident macrophages of the central nervous system, play important roles in immune responses and pathogenesis. Japanese encephalitis virus (JEV) is a neurotropic virus that infects microglial cells in brain. Several microRNAs including miR-155 and miR-146a play an important role in defining the microglia inflammatory profile.

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Clastogenicity of carbazole was evaluated by employing mouse in vivo chromosomal aberration (CA) test. Carbazole administered intraperitoneally (i.p.

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