Predictive Model for Dyslexia from Fixations and Saccadic Eye Movement Events.

Background: Dyslexia is a disorder characterized by difficulty in reading such as poor speech and sound recognition. They have less capability to relate letters and form words and exhibit poor reading comprehension. Eye-tracking methodologies play a major role in analyzing human cognitive processing.

Saccharification of macroalgal polysaccharides through prioritized cellulase producing bacteria.

Marine macroalgal cell wall is predominantly comprised of cellulose (polysaccharide) with the complex chain of glycosidic linkages. Bioethanol production from macroalgae entails breaking this complex chain into simple glucose molecule, which has been the major challenge faced by the industries. Cellulases have been preferred for hydrolysis of cellulose due to the absence of inhibitors affecting the subsequent fermentation process.

Screening of potential probiotic lactic acid bacteria and production of amylase and its partial purification.

Probiotics are the healthy living bacteria when administered in adequate amounts confers health benefits in the host. The main objective of present study was to screen the bacteria for potential probiotic characters and enzyme production. The probiotic characters like tolerance to low pH, bile salts, antibiotic sensitivity, hydrophobicity and auto-aggregation properties were evaluated.

Lipase catalyzed transesterification of ethyl butyrate synthesis in -hexane- a kinetic study.

Kinetics of lipase catalyzed transesterification of ethyl caprate and butyric acid was investigated. The objective of this work was to propose a reaction mechanism and develop a rate equation for the synthesis of ethyl butyrate by transesterification using surfactant coated lipase from . The reaction rate could be described in terms of Michaelis-Menten equation with a Ping-Pong Bi-Bi mechanism and competitive inhibition by both the substrates.

Anchoring transition induced by gelation in a liquid crystal system.

We report a novel type of anchoring transition (ANT) in a liquid crystal driven by the physical gelation of the system. The ANT manifests as anomaly in the thermal behaviour of the dielectric permittivity. Data from X-ray studies suggest that ANT is caused by the ability of the gel fibres to compete with the substrate-driven orientation conditions.

Soft glass rheology in liquid crystalline gels formed by a monodisperse dipeptide.

Thermal and extensive rheological characterization of a nematic liquid crystal gelated with a novel monodisperse dipeptide, also a liquid crystal, has been carried out. For certain concentrations, the calorimetric scans display a two-peak profile across the chiral nematic-isotropic (N*-I) transition, a feature reminiscent of the random-dilution to random-field crossover observed in liquid crystal gels formed with aerosil particles. All samples show shear thinning behavior without a Newtonian plateau region at lower shear rates.

A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations.

In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous domains.

Modeling analysis of GST (glutathione-S-transferases) from Wuchereria bancrofti and Brugia malayi.

GST (glutathione S-transferases) are a family of detoxification enzymes that catalyze the conjugation of reduced GSH (glutathione) to xenobiotic (endogenous electrophilic) compounds. GST from Wb (Wuchereria bancrofti) and Bm (Brugia malayi) are significantly different from human GST in sequence and structure. Thus, Wb-GST and Bm-GST are potential chemotherapeutic targets for anti-filarial treatment.

Structural and active site analysis of plasmepsins of Plasmodium falciparum: potential anti-malarial targets.

Comparative protein modeling, active site analysis and binding site specificity for the homologous series of plasmepsins (PM's), present in food vacuole of Plasmodium falciparum, are carried out. Four loops (L1, L2, L3 and L4), which show maximum structural deviations irrespective of type of inhibitor, have been identified. Comparison of the crystal structures of ligand complexes reveal that residues belonging to these loops have negligible coulomb and VDW interactions with the inhibitor but play major role in determining the openness of the binding cavity.