Publications by authors named "Bhargavi Gangula"
Article Synopsis
- High levels of apoB in LDL and low levels of apoA1 in HDL contribute to atherosclerosis, prompting researchers to find a molecular regulator that can balance both lipoproteins.
- In a study using human liver cells, miR-541-3p was identified as a key regulator that reduces apoB while increasing apoA1, by degrading specific transcription factors (Znf101 and Casz1) that control their expression.
- Experiments in mice showed that knocking down related genes altered lipoprotein levels and decreased atherosclerosis without causing fat accumulation in the liver, indicating that miR-541-3p and its targets could be potential therapies for cardiovascular diseases.
