Publications by authors named "Bhargav Bhimani"
Article Synopsis
- Synthetic routes of chromene are gaining attention due to their use in various applications including pigments, cosmetics, and pharmaceuticals.
- The chromene structure is vital for discovering new drugs with diverse pharmacological benefits, but traditional synthesis methods often pose environmental risks.
- Eco-friendly production methods are being developed, utilizing sustainable materials and safer techniques like microwave irradiation and ultrasound synthesis, offering advantages in scalability and purification.
Article Synopsis
- Multi-target directed ligands (MTDLs) are being researched for their effectiveness against Alzheimer's disease by addressing multiple aspects of the condition, like enzyme inhibition and metal balance.
- The study synthesized piperazine-quinoline-based MTDLs using a specific chemical reaction and found that certain compounds showed strong activity against the enzymes AChE and BuChE.
- Among the compounds, compound (95) showed the best inhibitory effects on both enzymes, while also demonstrating antioxidant properties and metal-chelating abilities, suggesting it could be a promising candidate for further Alzheimer's research.
In silico analysis, synthesis and biological evaluation of DHFR inhibitors.
Folia Med (Plovdiv)
October 2021
Introduction: Malaria is one of the varieties of fatal diseases caused by a protozoan parasite that is now considered to be the greatest global health challenge. A parasite of Plasmodium species triggers it transmitting the disease to humans by the bites of female Anopheles mosquitoes.
Aim: To screen out designed molecules by molecular docking analysis and assess their pharmacokinetic properties using SwissADME.
The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer's Disease.
CNS Neurol Disord Drug Targets
August 2021
Beta site amyloid precursor protein cleaving enzyme 1 (BACE1) is a rational target in Alzheimer's Disease (AD) drug development due to its role in amyloidogenic cleavage of Amyloid Precursor Protein (APP) in generating Amyloid β (Aβ). This β-secretase cleaves not only Amyloid Precursor Protein (APP) and its homologues, but also small series of substrates including neuregulin and β subunit of voltage-gated sodium channel that play a very important role in the development and normal function of the brain. Moreover, BACE1 is modulated at the post-translational level by several factors that are associated with both physiological and pathological functions.
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