Nanoscale size impact of nanoparticle interaction and activity studies with urease.

Herein, we provide insights into the size-dependent interactions of silver nanoparticles (AgNPs) with urease and their implications for enzyme inhibition. AgNPs with a size of 5 nm exhibited the strongest binding affinity of 66 nM, resulting in significant enzyme attachment, interfering enzyme conformation, and a consequent loss of activity. Mid-sized AgNPs, , 20 and 50 nm, exhibited binding affinities of 712 and 616 nM, causing only slight structural alterations.

A Validated Method for Identification and Quantification of Anthocyanins in Different Black Rice (Oryza sativa L.) Varieties Using High-Performance Thin-Layer Chromatography (HPTLC).

Introduction: Black rice (Oryza sativa L.) has gained prominence as a functional food because of its rich content of anthocyanins and polyphenols, offering potential health benefits. However, comprehensive research addressing the diverse anthocyanin compositions in black rice cultivars remains limited.

Unveiling Gelation and Antimicrobial Potentials of α-Acyloxy Carboxamides: Findings from Experimental and Theoretical Approach.

Multicomponent reactions have long been recognized as some of the most versatile tools in organic chemistry, with extensive applications in biomedical science and the pharmaceutical industry. In this study, we explored the potential of the Passerini reaction by designing and synthesizing new low molecular mass gelators that can serve as novel formulations for prolonged anesthesia. These gelators address critical issues like poor solubility, low bioavailability, and short plasma half-life, all of which hinder therapeutic efficacy.

Cross Sectional Study of Vitamin D Levels in Western Rajasthan and Meta-Analysis for Estimation of Vitamin D Levels.

Many studies showed Vitamin D deficiency is highly prevalent in healthy individuals. We planned to study the normal levels of Vitamin D in healthy individuals and make recommendation for defining deficiency of 25(OH)D in Indian population. ormal healthy subjects 18 to 60 years of age were included.

Correction: Cross Sectional Study of Vitamin D Levels in Western Rajasthan and Meta-Analysis for Estimation of Vitamin D Levels.

[This corrects the article DOI: 10.1007/s12291-022-01074-4.].

Predicting Paediatric Brain Disorders from MRI Images Using Advanced Deep Learning Techniques.

The problem at hand is the significant global health challenge posed by children's diseases, where timely and accurate diagnosis is crucial for effective treatment and management. Conventional diagnosis techniques are typical, use tedious processes and generate inaccurate results since they are executed by human beings and cause delays in treatment that can be fatal. Considering these and other shortcomings there exists a need to have more efficient and accurate solutions based on artificial intelligence.

Capsaicin content in chillies ( L., s L., Jacq.) of Northeast India by high performance thin layer chromatography (HPTLC).

Capsaicin is the primary bioactive constituent in chillies, responsible for its incomparable pungent taste and many health advantages. In the current study, 32 samples of three different species of ( L., s L.

mHealth-based intervention by community workers to support family caregivers of persons with dementia living at home: study protocol for a cluster randomised controlled trial.

Background: India is undergoing a significant demographic shift with a growing older population, leading to an anticipated increase in people with dementia. Family caregivers, who are predominantly informal, carry the burden of care within households, facing numerous challenges that impact their well-being. Despite the cultural emphasis on family support, there is a lack of targeted interventions for caregivers in India.

Volar Plate Draping (VPD) for Severely Comminuted Proximal Phalanx Head Fractures.

While proximal phalangeal joint injuries with comminution of the base of the middle phalanx are common injuries, proximal interphalangeal (PIP) joint fracture dislocations with an intact base of middle phalanx and a comminuted head of proximal phalanx are rare. Volar plate arthroplasty and other described techniques prevail for the former injury, while the latter does not have any supportive literature on the exact method of management. We herein present a 20-year-old male with a severely comminuted head of proximal phalanx fracture with dislocation of the PIP joint, which was not reconstructable but was managed successfully with a novel technique of volar plate draping that resurfaced the raw phalangeal head.

SkinSage XAI: An explainable deep learning solution for skin lesion diagnosis.

Background: Skin cancer poses a significant global health threat, with early detection being essential for successful treatment. While deep learning algorithms have greatly enhanced the categorization of skin lesions, the black-box nature of many models limits interpretability, posing challenges for dermatologists.

Methods: To address these limitations, SkinSage XAI utilizes advanced explainable artificial intelligence (XAI) techniques for skin lesion categorization.

Investigating emergency rescue readiness on Indian national highways: A case study of Jaipur-Jodhpur Highways (India) using a geospatial approach.

Background: Highways represent the most significant capital asset that any country's public sector holds. A system of national highways with easy access to ambulance and trauma centers is termed emergency rescue ready and helps reduce the mortality due to road accidents. Given the rich impetus for road infrastructure development by the government of India, there is a need to consider emergency rescue readiness on highways.

Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study.

Introduction: Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.

Methods And Analysis: We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India.

Comprehensive virome profiling of sugarcane and simplified duplex OneStep RT-PCR assay reveals the prevalence of sugarcane streak mosaic virus along with sugarcane yellow leaf virus in India.

Background: Sugarcane is host of many viral pathogens that affects its growth and productivity. High-throughput sequencing (HTS) is comprehensive diagnostic platform that permit the precise detection of viral pathogens to resolve the disease epidemiology of the crop, thus providing the phytosanitary status of plants. The current work was designed to comprehend the virome profiling of sugarcane belonging to five varieties collected from the major crop producing states in India.

A terpyridine-based copper complex for electrochemical reduction of nitrite to nitric oxide.

In biological systems, nitrite reductase enzymes (NIRs) are responsible for reduction of nitrite (NO) to nitric oxide (NO). These NIRs have mostly Cu- or Fe-containing active sites, surrounded by amine-containing ligands. Therefore, mononuclear Cu complexes with N-donor ligands are highly relevant in the development of NIR model systems and in the mechanistic investigation of the nitrite reduction reaction.

AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability.

Chemical risk assessment plays a pivotal role in safeguarding public health and environmental safety by evaluating the potential hazards and risks associated with chemical exposures. In recent years, the convergence of artificial intelligence (AI), machine learning (ML), and omics technologies has revolutionized the field of chemical risk assessment, offering new insights into toxicity mechanisms, predictive modeling, and risk management strategies. This perspective review explores the synergistic potential of AI/ML and omics in deciphering clastogen-induced genomic instability for carcinogenic risk prediction.

Considerations in Correction of Wrist Deformity in Arthrogryposis.

The wrist is affected in all the forms of arthrogryposis and is a common site requiring surgical intervention. The wrist usually has a flexion and ulnar deviation deformity of varying severity. A flexion deformity of >40° results in a weak hand grip and gives an 'abnormal' look to the patient as a whole and hence, is a common reason for patients to desire surgical correction.

Channel width modulates the permeability of DNA origami-based nuclear pore mimics.

Nucleoporins (nups) in the nuclear pore complex (NPC) form a selective barrier that suppresses the diffusion of most macromolecules while enabling rapid transport of nuclear transport receptor (NTR)-bound cargos. Recent studies have shown that the NPC may dilate and constrict, but how altering the NPC diameter affects its selective barrier properties remains unclear. Here, we build DNA nanopores with programmable diameters and nup arrangements to model the constricted and dilated NPCs.

[Not Available].

Up to 70% of all sudden cardiac deaths (SCD) in persons under 50 years are due to inherited cardiovascular diseases. First-degree relatives to younger SCD patients should be evaluated for inherited cardiovascular disease, as argued in this review. An improved understanding of SCD subtypes and genetics is expected to improve risk stratification and SCD prevention.

Effect of tele-yoga on burnout, mental health and immune markers of health care workers on COVID-19 duty: An open-label parallel group pilot randomized controlled trial.

Background: The COVID-19 pandemic overburdened the healthcare system and affected the mental health of healthcare workers. Yoga has proven to improve mental health correlates, within diverse population groups, including healthcare workers. Considering the pandemic-imposed restrictions, this trial was designed to study the feasibility and effect of tele-yoga intervention on burnout, sleep quality, depression, anxiety, stress, mindfulness, and immune markers of healthcare workers on COVID-19 duty.

Updates in Treatment of HER2-positive Metastatic Breast Cancer.

The therapeutic landscape for HER2-positive metastatic breast cancer has exploded in the last two decades following the initial advent of trastuzumab, a monoclonal antibody. While the first line treatment has remained a combination of dual HER2 blockade with taxane chemotherapy, we now have several exciting options in the second line and beyond. The introduction of antibody-drug conjugates, in specific trastuzumab deruxtecan, has resulted in the best progression-free survival among patients with this subtype of breast cancer.

Nanocatalysis of silver-nanobioprobe based supersensitive electrochemical detection of Salmonella serotypes targeting virulence protein.

Herein, we report a supersensitive and specific detection of Salmonella employing nanocatalysis of silver nanoparticle (AgNp). A nanobioprobe was developed employing specific antibody (Ab) that binds to a peptide present in transmembrane protein of Salmonella. We have studied 7 surface-exposed peptide hits from conserved virulence proteins (PagC, ST50, PagN, CdtB and FliC).

Editorial commentary: "Three steps to ACM diagnosis - is it that easy?".

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease which predisposes to ventricular arrhythmias and sudden cardiac death. Since the introduction of the first diagnostic criteria in 1994, which focused exclusively on right ventricular involvement, diagnostic guidelines have evolved significantly over the past 30 years to encompass the full complexity of the ACM phenotype. In this issue of Trends in Cardiovascular Medicine, Graziano and colleagues review the advancements in ACM diagnostics which emphasizes a comprehensive evaluation of morpho-functional, structural, electrical, and genetic characteristics.