Publications by authors named "Bharathiraja Chinnapandi"

Diseases caused by plant-parasitic nematodes in vegetables, among them Meloidogyne spp. root-knot nematodes (RKNs), lead to extensive yield decline. A molecular understanding of the mechanisms underlying plants' innate resistance may enable developing safe alternatives to harmful chemical nematicides in controlling RKNs.

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Article Synopsis
  • The study analyzed how the tomato's WRKY defense regulator, SlWRKY45, changes during infection by the nematode Meloidogyne javanica, focusing on its expression over time and in different tissues.
  • SlWRKY45 expression significantly increased within five days of infection, particularly in feeding cells, and was strongly induced by phytohormones like cytokinin and auxin but not by jasmonates.
  • Overexpressing SlWRKY45 in tomato roots led to more nematode females, suggesting this regulator helps create conditions that support nematode development while suppressing defense-related genes.
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Metagenomics research has been developed over the past decade to elucidate the genomes of the uncultured microorganisms with an aim of understanding microbial ecology. On the other hand, it has also been provoked by the increasing biotechnological demands for novel enzymes, antibiotic and signal mimics. The gut microbiota of insects plays crucial roles in the growth, development and environmental adaptation to the host insects.

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Currently, pre-clinical and clinical studies have demonstrated the importance of stem cell based therapies for the treatment of human diseases. Fetal Mesenchymal Stem Cells (Fetal MSCs) are potential candidates that can be utilized for the treatment of different types of cancer. Recently, Wharton's jelly (umbilical cord matrix) was proved to be a rich source of MSCs and they can be isolated by non-invasive methods such as Ficoll density gradient and antibodies coupled magnetic beads without any ethical issues.

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