Three-dimensional movement and distribution of Tribolium castaneum (Coleoptera: Tenebrionidae) and Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) in stored wheat at different temperatures and at different times.

Understanding the movement and distribution patterns of insects is crucial for developing effective stored grain management protocols. This research investigates 3-dimensional movement and distribution of Tribolium castaneum (Herbst) and Cryptolestes ferrugineus (Stephens) separately at different temperatures (5, 10, 20, and 30°C) and for different movement periods (1, 2, 3, and 24 h) in stored wheat with a uniform moisture content of 14.5% (wet basis).

Evolution of Bionanocomposites: Innovations and Applications in Food Packaging.

Bionanocomposites are emerging as a pivotal innovation in sustainable food packaging, leveraging the strengths of biopolymers enhanced with nanoparticles for improved functionality. The increasing demand for sustainable packaging solutions, coupled with advancements in nanotechnology, has driven research in this field over the past decade. This review covers the full spectrum of developments in the field, from the classification and synthesis of bionanocomposites to their applications in food packaging and current research trends.

Therapeutic targeting of the oxidative stress generated by pathological molecular pathways in the neurodegenerative diseases, ALS and Huntington's.

Neurodegenerative disorders are characterized by a progressive decline of specific neuronal populations in the brain and spinal cord, typically containing aggregates of one or more proteins. They can result in behavioral alterations, memory loss and a decline in cognitive and motor abilities. Various pathways and mechanisms have been outlined for the potential treatment of these diseases, where redox regulation is considered as one of the most common druggable targets.

Activation of the yeast MAP kinase, Slt2, protects against TDP-43 and TDP-25 toxicity in the Saccharomyces cerevisiae proteinopathy model.

TDP-43 proteinopathy is observed in human neurodegenerative diseases like ALS. Heterologous TDP-43 expression in the yeast model also mimics several proteinopathy features such as cytotoxicity, cytoplasmic mis-localization and oxidative stress. Among the pathways implicated in modulating the TDP-43 toxicity in yeast, the unfolded protein response (UPR) activation was also identified.

Innovations in nondestructive assessment of baked products: Current trends and future prospects.

Rising consumer awareness, coupled with advances in sensor technology, is propelling the food manufacturing industry to innovate and employ tools that ensure the production of safe, nutritious, and environmentally sustainable products. Amidst a plethora of nondestructive techniques available for evaluating the quality attributes of both raw and processed foods, the challenge lies in determining the most fitting solution for diverse products, given that each method possesses its unique strengths and limitations. This comprehensive review focuses on baked goods, wherein we delve into recently published literature on cutting-edge nondestructive methods to assess their feasibility for Industry 4.

Phytofabrication of biocompatible chitosan-based ZnO nanocomposite aided by Cissus quadrangularis extract enriched with antimicrobial and antioxidant potential.

A dynamic chitosan-based ZnO nanocomposite (NC) was fabricated via a cost-effective formulation and an eco-friendly procedure utilizing Cissus quadrangularis (CQ) plant extract. This study investigates the antimicrobial and antioxidant properties, together with the cytocompatibility aspects of chitosan-incorporated ZnO nanocomposite (CS-ZnO/CQE). The formation and structural morphology of the nanocomposites were examined using FTIR, UV-Vis, XRD, XPS, BET, TGA, SEM, and TEM techniques.

Biology, Ecology, and Behavior of Rusty Grain Beetle ( (Stephens)).

, the rusty grain beetle, is a cosmopolitan pest that has adapted to cool and warm climates due to its unique biology, ecology, and behavior. The rusty grain beetle is a pest of high economic importance; hence, understanding their biology, ecology, and behavior could be useful in designing effective management strategies. An extensive literature survey was conducted using the databases Web of Science and Scopus.

Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice.

The chemotherapeutic drug doxorubicin is cardiotoxic and can cause irreversible heart failure. In addition to being cardiotoxic, doxorubicin also induces the activation of coagulation. We determined the effect of thrombin-mediated activation of protease-activated receptor 1 (PAR1) on doxorubicin-induced cardiac injury.

Effects of Insect Density, Movement Period, and Temperature on Three-Dimensional Movement and Distribution of Adult Cryptolestes ferrugineus (Coleoptera: Laemophloeidae).

Knowledge on three-dimensional (3D) movement and distribution of Cryptolestes ferrugineus (Stephens) (Coleoptera: Laemophloeidae) in grain bulks assists in the prediction of their distribution inside a bin. The following experiments were conducted to determine the 3D dispersal patterns of adult C. ferrugineus in wheat with 14.

Serum biomarkers of maternal morbidity and adverse outcome in severe pre-eclampsia.

Objective: To evaluate the association of maternal serum biomarkers of myocardial damage, oxidative stress and angiogenic imbalance with maternal adverse outcomes in women with severe pre-eclampsia.

Methods: This was a prospective cohort study, where maternal serum biomarkers were evaluated in women admitted with severe pre-eclampsia to a tertiary care centre between March 2019 and February 2020. Serum markers included brain naturetic peptide (BNP), cardiac troponin-T (cTnT), cystatin-C (cys-C), soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), Total Anti-Oxidant status (TAO) and malondialdehyde (MAO).

Elevated constitutive expression of Hsp40 chaperone Sis1 reduces TDP-43 aggregation-induced oxidative stress in Ire1 pathway dependent-manner in yeast TDP-43 proteinopathy model of amyotrophic lateral sclerosis.

Oxidative stress is a therapeutic target in TDP-43 proteinopathies like amyotrophic lateral sclerosis (ALS) and FTLD-TDP. TDP-43 over-expression causes oxidative stress in yeast model of ALS. Previously, we developed a red/white color conversion reporter assay using ade1 or ade2 mutant yeast to examine oxidative stress induced by expression of amyloidogenic proteins.

Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice.

Background: Innate immune responses to influenza A virus (IAV) infection are initiated in part by toll-like receptor 3 (TLR3). TLR3-dependent signaling induces an antiviral immune response and an NFκB-dependent inflammatory response. Protease-activated receptor 2 (PAR2) inhibits the antiviral response and enhances the inflammatory response.

Genetic deletion of platelet PAR4 results in reduced thrombosis and impaired hemostatic plug stability.

Background: Protease-activated receptor 4 (PAR4) is expressed by a wide variety of cells, including megakaryocytes/platelets, immune cells, cardiomyocytes, and lung epithelial cells. It is the only functional thrombin receptor on murine platelets. A global deficiency of PAR4 is associated with impaired hemostasis and reduced thrombosis.

Three-dimensional Movement and Distribution of Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) Adults in Stored Wheat Under Constant Temperatures and Moisture Contents.

Understanding the movement and distribution of insects inside a grain bin is crucial to develop an effective stored grain management protocol. The three-dimensional movement and distribution of adult Cryptolestes ferrugineus (Stephens) at 20 and 30°C were determined in a 0.7 × 0.

Amyloid-like aggregation of bovine serum albumin at physiological temperature induced by cross-seeding effect of HEWL amyloid aggregates.

BSA can form amyloid-like aggregates in vitro at 65 °C. Heterologous amyloid can proposedly cross-seed other protein's aggregation, however, general mechanisms and driving conditions remain to be vividly elucidated. Here, we examined if pre-formed HEWL amyloid can cross-seed the aggregation of BSA at physiological temperature, 37 °C, and whether the efficacy depends on the BSA conformation.

Successful Triplet Pregnancy Post-Allogeneic Stem Cell Transplant in a Patient With Doxorubicin-Induced Cardiomyopathy.

We report the unique case of a patient who recovered cardiac function despite a history of doxorubicin-induced cardiomyopathy, chest radiation therapy, high dose chemotherapy post-allogeneic stem cell transplant, and triplet pregnancy. Data are sparse on doxorubicin-induced cardiomyopathy in pregnant patients, calling for further studies to help formulate management or surveillance recommendations. ().

Cell type-specific roles of PAR1 in Coxsackievirus B3 infection.

Protease-activated receptor 1 (PAR1) is widely expressed in humans and mice, and is activated by a variety of proteases, including thrombin. Recently, we showed that PAR1 contributes to the innate immune response to viral infection. Mice with a global deficiency of PAR1 expressed lower levels of CXCL10 and had increased Coxsackievirus B3 (CVB3)-induced myocarditis compared with control mice.

Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS.

TDP-43 protein is found deposited as inclusions in the amyotrophic lateral sclerosis (ALS) patient's brain. The mechanism of neuron death in ALS is not fully deciphered but several TDP-43 toxicity mechanisms such as mis-regulation of autophagy, mitochondrial impairment and generation of oxidative stress etc., have been implicated.

Zn modulates in vitro phase separation of TDP-43 and mutant TDP-43-A315T C-terminal fragments of TDP-43 protein implicated in ALS and FTLD-TDP diseases.

TDP-43 proteinopathy is implicated in the neurodegenerative diseases, ALS and FTLD-TDP. Metal ion dyshomeostasis is observed in neurodegenerative diseases including ALS. Previously, mice expressing A315T familial ALS TDP-43 mutant showed elevated spinal cord Zn levels.

PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus.

Background: Protease-activated receptor 1 (PAR1) is expressed in various immune cells and in the lung. We showed that PAR1 plays a role in Coxsackievirus B3 infection by enhancing toll-like receptor 3-dependent interferon- expression in cardiac fibroblasts.

Objectives: We investigated the role of PAR1 in a mouse model of influenza A virus (IAV) infection.

Attractiveness of Male and Female Adults of Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) to Conspecifics With and Without Grain.

Whether stored-grain insects can communicate with each other inside stored-grain bulks is an important question for the development of pest management programs. Movements of the individual adults of Cryptolestes ferrugineus towards caged adult(s), in the presence or absence of wheat, were studied inside an apparatus (10 cm length), using an infrared camera. The numbers of the caged adults were 1, 20, or 50 of females or males, and 100 or 200 mixed-sex adults.

Characterization and distribution of microplastics and plastic debris along Silver Beach, Southern India.

Microplastics are causing serious environmental threats worldwide. To evaluate the current state of microplastics pollution, 28 sediment samples were examined for microplastics and plastic debris contamination along Silver Beach, Southern India. Visual identification followed by FT-IR spectroscopy was used to estimate the overall distribution and characterization of plastic debris.