Publications by authors named "Bharathi Raja Ainan"
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Synopsis of recent research by authors named "Bharathi Raja Ainan"
- Bharathi Raja Ainan's research primarily focuses on the discovery and development of novel small molecule inhibitors targeting key kinases involved in hematologic malignancies, such as IRAK4 and ALK
- The article "Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor" highlights the synthesis of CA-4948, showing its potent activity in DLBCL and AML cell lines and its ability to inhibit TLR signaling, thereby reducing IL-6 levels
- In the study on 7-azaindole based ALK inhibitors, Ainan's team identified compounds that exhibit excellent potency and a unique binding mode, contributing to improved therapeutic options for cancers driven by ALK mutations
