Publications by authors named "Bharath Sampath Kumar"
The application of ambient mass spectrometry imaging "MSI" is expanding in the areas of fundamental research on drug delivery and multiple phases of the process of identifying and developing drugs. Precise monitoring of a drug's pharmacological workflows, such as intake, distribution, metabolism, and discharge, is made easier by MSI's ability to determine the concentrations of the initiating drug and its metabolites across dosed samples without losing spatial data. Lipids, glycans, and proteins are just a few of the many phenotypes that MSI may be used to concurrently examine.
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- Tissue analysis is crucial for diagnosing and predicting illnesses like cancer, with frozen section histopathology being a challenging and subjective method used during surgeries.
- Recent advancements in mass spectrometry imaging (MSI) allow for the simultaneous visualization of numerous molecules in tissue biopsies, offering a major improvement over traditional histopathology's single optical imaging.
- This article reviews the innovative desorption electrospray ionization mass spectrometry imaging (DESI-MSI) technique, which is label-free and minimally invasive, highlighting its potential in providing diagnostic insights by analyzing molecular differences in healthy and diseased tissues from 2018 to 2023.