Publications by authors named "Bharath S Padya"
Article Synopsis
- The study addresses the limitations of the anticancer drug 5-fluorouracil (5-FU), including its rapid metabolism and drug resistance, by developing a novel topical gel using metal-organic frameworks (MOFs) for skin cancer treatment.
- This new formulation, 5-FU@ZIF-8-SDG, combines 5-FU with ZIF-8 MOFs and a targeting agent (sonidegib) to enhance skin penetration and retention related to its therapeutic effects.
- Experimental results show that the gel formulation significantly inhibits cell growth in cancer cells while being biocompatible with normal cells, suggesting its potential as an effective treatment for basal cell carcinoma (BCC).
Development of Lipidic Nanoplatform for Intra-Oral Delivery of Chlorhexidine: Characterization, Biocompatibility, and Assessment of Depth of Penetration in Extracted Human Teeth.
Nanomaterials (Basel)
September 2022
Article Synopsis
- Microorganisms often lead to the failure of root canal treatments due to their ability to penetrate root structures, complicating irrigation effectiveness because of biofilm growth.
- This study aimed to create liposomes containing chlorhexidine to improve antibacterial action and penetration into dentinal tubules compared to standard chlorhexidine solutions.
- Results showed that liposomal chlorhexidine had a better penetration depth in tooth roots and had lower cytotoxic effects on mouse fibroblast cells while also being more effective at reducing bacterial colony counts.*
Topical drug delivery provides several benefits over other conventional routes by providing localizing therapeutic effects and also avoids the gastrointestinal tract circumventing the first-pass metabolism and enzymatic drug degradation. Being painless, the topical route also prevents the difficulties linked with the parenteral route. However, there are limitations to the current topical systems which necessitate the need for further research to find functional excipients to overcome these limitations.
View Article and Find Full Text PDFTo develop a new sensitive RP-HPLC method for simultaneous estimation of 5-fluorouracil (5-FU) and sonidegib (SDG). Analytical and bioanalytical methods for simultaneous quantification of 5-FU and SDG in bulk, nanoformulations and in rat plasma were developed and validated using a gradient elution technique. Separation of the analytes was effected on a Luna C18 LC column using a mobile mixture comprising acetonitrile and acidified water.
View Article and Find Full Text PDFNovel bioactive formulation derived from the conditioned medium of mesenchymal stromal cells reduces under-eye dark circles in human volunteers.
J Cosmet Dermatol
February 2022
Background: Under-eye dark circles are a common condition observed in dermatology practice. Mesenchymal stromal cell-derived conditioned medium (MSC-CM) contains an array of growth factors and cytokines reported to promote periorbital rejuvenation and may be useful in removing the dark circle around the eyes.
Aims: The aim of the present study was to evaluate the safety and efficacy of developed bioactive formulation containing mesenchymal stromal cell-derived conditioned medium in reducing the under-eye dark circles.
Article Synopsis
- - Black phosphorus (BP) is a new two-dimensional material being explored in biomedicine due to its unique properties, making it suitable for applications in optoelectronics, bioimaging, and 3D printing.
- - The review highlights various synthetic methods, structural properties, and characterization techniques of BP, including Raman spectroscopy, which are crucial for understanding its potential in drug delivery and cancer therapy.
- - The text discusses the multifunctional use of BP and BP-based materials in medical applications, particularly focusing on their roles in therapy and imaging for cancer treatment through methods like photoacoustic and fluorescence imaging.
Although extensive research is being done to combat SARS-CoV-2, we are yet far away from a robust conclusion or strategy. With an increased amount of vaccine research, nanotechnology has found its way into vaccine technology. Researchers have explored the use of various nanostructures for delivering the vaccines for enhanced efficacy.
View Article and Find Full Text PDFInterdisciplinary applications of nanopharmaceutical sciences have tremendous potential for enhancing pharmacokinetics, efficacy and safety of cancer therapy. The limitations of conventional therapeutic platforms used for skin cancer therapy have been largely overcome by the use of nanoplatforms. This review discusses various nanotechnological approaches experimented for the treatment of skin cancer.
View Article and Find Full Text PDFArticle Synopsis
- * The review explores the structure and transmission of SARS-CoV-2, comparing it with similar viruses like SARS and MERS, while outlining potential therapeutic strategies, including drug repurposing.
- * It summarizes the current status of clinical trials for therapies and vaccines, along with insights into recent advancements and future research directions for combating COVID-19.