Publications by authors named "Bharat L Meena"
Article Synopsis
- The study presents a portable device that measures polarized fluorescence to analyze cervical cancer, focusing on the fluorophore flavin adenine dinucleotide (FAD) as a key indicator.
- The device uses specific laser and white light to gather data, with adjustments made to overcome challenges from scattering and absorption of light in the measurement process.
- Results show that changes in FAD concentration effectively differentiate between various cancer grades, with high sensitivity and specificity rates for identifying early-stage cervical cancer, suggesting the device's potential for early diagnostics.
An in-house fabricated portable device has been tested to detect cervical precancer through the intrinsic fluorescence from human cervix of the whole uterus in a clinical setting. A previously validated technique based on simultaneously acquired polarized fluorescence and polarized elastic scattering spectra from a turbid medium is used to extract the intrinsic fluorescence. Using a diode laser at 405 nm, intrinsic fluorescence of flavin adenine dinucleotide, which is the dominant fluorophore and other contributing fluorophores in the epithelium of cervical tissue, has been extracted.
View Article and Find Full Text PDF