The dynamic DNA methylation landscape of the shore is altered by -93G>A polymorphism in normal tissues and colorectal cancer.

Background: Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. Expression of (), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tumours due to mutation or, more commonly, due to DNA methylation of its promoter CpG island. A single nucleotide polymorphism (SNP) in the CpG island of (-93G>A or rs1800734) is associated with CpG island hypermethylation and decreased expression in CRC tumours.