Validation of the GPAT - the Global Polypectomy Assessment Tool: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

BACKGROUND : Colorectal polypectomy is operator dependent, with variable rates of complete resection. The currently available assessment tools do not provide specific competency-based evaluation of provider technique. We aimed to validate the Global Polypectomy Assessment Tool (GPAT), a novel competency assessment tool for colorectal polypectomy.

Variability in computer-aided detection effect on adenoma detection rate in randomized controlled trials: A meta-regression analysis.

Background: Computer-aided detection (CADe) systems may increase adenoma detection rate (ADR) during colonoscopy. However, the variable results of CADe effects in different RCTs warrant investigation into factors influencing these results.

Aims: Investigate the different variables possibly affecting the impact of CADe-assisted colonoscopy and its effect on ADR.

Causes and Outcome of Neurogenic Vision Loss.

Background: Neurogenic vision loss is often a medical emergency. Early evaluation and urgent treatment of the causes is the key to better visual prognosis.

Methods: This was a retrospective cross-sectional study based on hospital records of patients admitted to the Neurology department of Tribhuvan University Teaching Hospital with complain of diminution of vision from April 2023 to March 2024.

The Impact of International Fellowship on Research Productivity: International Fellowship on Research Productivity.

International medical graduates (IMGs) represent a significant portion of the US physician workforce, comprising 25% across all specialties with a strong presence in internal medicine and primary care. However, their representation in plastic surgery remains limited at only 10%. Matching into a US plastic surgery residency is highly competitive for both US medical graduates and IMGs.

Ferumoxytol-enhanced MRI of retroplacental clear space disruption in placenta accreta spectrum.

Introduction: Placenta accreta spectrum (PAS) occurs when the placenta is pathologically adherent to the myometrium. An intact retroplacental clear space (RPCS) is a marker of normal placentation. In this study, we investigate use of the FDA-approved iron supplement ferumoxytol for contrast-enhanced MRI of the RPCS in mouse models of normal pregnancy and PAS.

One health assessment of farmers' knowledge, attitudes, and practices (KAPs) on zoonoses in Bangladesh.

In Bangladesh, farming serves as a key livelihood, leading to a higher risk of zoonotic diseases due to frequent animal interactions and traditional practices. The study aimed to assess the knowledge, attitudes, and practices of livestock farmers regarding zoonotic disease outbreaks. A cross-sectional study was conducted with 658 livestock farmers from randomly selected regions in Bangladesh from April to June 2024.

Copigmentation effect on red cabbage anthocyanins, investigation of their cellular viability and interaction mechanism.

Anthocyanins (ANS) are an appealing substitute to synthetic colorants; but their practical applicability is limited due to low color stability. Copigmentation can improve both complex's color stability as well as intensity. In this study, we examined the interaction of red cabbage ANS with copigments i.

Screening of Breast among Women: A Cross-Sectional Study in Nepal.

Background: Breast cancer ranks as the second most prevalent malignancy among women in Nepal. This cancer has a high likelihood of cure, if detected early. Therefore, it is imperative to emphasize awareness and screening for breast cancer in Nepal.

An infected intracranial dermoid cyst at the region of torcular herophili: A case report.

Background: Dermoid cysts result from embryonic fusion anomalies, with intracranial dermoid cysts being rare (0.1-0.7% of intracranial tumors).

Steroid-Induced Psychosis in a Child With Nephrotic Syndrome Secondary to Focal Segmental Glomerulosclerosis: A Case Report.

Corticosteroid-induced psychosis is rare and less reported in children compared to adults. However, psychosis is considered a severe adverse effect of corticosteroids in pediatric nephrotic syndrome. Steroid-induced psychosis is dose-dependent and should be treated by tapering the dose of steroids and usually initiating an atypical antipsychotic.

Real-time intervention to increase daily chlorhexidine bathing and reduce central line-associated bloodstream infections.

Background: After an increase of central line-associated bloodstream infections (CLABSIs) at our community hospital in 2021, a case-control study suggested that patients with CLABSIs were 3.0 times more likely to have missed daily chlorhexidine gluconate (CHG) bathing than patients without CLABSIs.

Objective: To increase the rate of daily CHG bathing in hospitalized patients with central lines and subsequently reduce the number of CLABSIs.

Management of Distal Radius Rim Fractures-Technical Pearls.

Distal radius fractures are common and vary based on their fracture pattern. Fractures distal to the watershed line are called rim fractures or marginal fractures. In addition to challenges already faced when treating distal radius fractures at other sites, rim fractures pose particular challenges in proper identification, reduction, and stabilization.

Vanderbilt University Rehabilitation Approach to Zone 2 Tendon Repairs in the Hand.

Zone 2 of the hand, which stretches from the region between the A1 pulley at the distal palmar crease to the insertion of the FDS tendon at the end of the A4 pulley, is notable for its high complication rate following surgery. Many of these complications, such as adhesions, contractures, and tendon rupture, can be avoided through adequate rehabilitation. We document the rehabilitation protocol at Vanderbilt University Medical center, which is characterized by 4 phases.

"Unraveling a rare encounter: Gorham's disease in an 88-year-old female".

Introduction And Importance: Gorham syndrome, or Gorham-Stout disease, is a rare disorder characterized by spontaneous and persistent bone resorption without any known cause, leading to severe complications [2]. The clinical presentation of this condition varies widely, complicating efforts in diagnosis and treatment. In our case report, we present the story of an 88-year-old woman who bravely and gracefully faced the challenges caused by Gorham syndrome.

Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3.

Acquisition of specialized cellular features is controlled by the ordered expression of transcription factors (TFs) along differentiation trajectories. Here, we find a member of the Onecut TF family, ONECUT3, expressed in postmitotic neurons that leave their Ascl1/Onecut1/2 proliferative domain in the vertebrate hypothalamus to instruct neuronal differentiation. We combined single-cell RNA-seq and gain-of-function experiments for gene network reconstruction to show that ONECUT3 affects the polarization and morphogenesis of both hypothalamic GABA-derived dopamine and thyrotropin-releasing hormone (TRH) glutamate neurons through neuron navigator-2 (NAV2).

An Improvised External Ventricular Drain Fixation Technique to Avoid Pullout-Related Complications in a Low-Resource Setting: A Descriptive Cross-Sectional Study in a Single Center of Nepal.

Background And Objectives: An external ventricular drain (EVD) placement is a commonly performed life-saving procedure. Its accidental pullout can occur in complex environments, patient care, and positioning, which leads to significant morbidity. The method of EVD fixation and pullout rates is sparsely described in the literature, and there exists a wide variation among the techniques practiced for fixation.

Effect of anisotropy and length dispersity on electrical and optical properties of nanowire network based transparent electrodes: a computational study.

We have studied the impact of nanowire alignment and measurement direction at the percolation threshold on the effective resistance () of two-dimensional (2D) films. This helps us to analyze the effect of anisotropy on the conductivity and transmittance of the nanowire-based network characterized by the disorder parameter (). These optoelectronic properties are determined for systems with monodisperse and bimodal length distribution (a combination of two fixed lengths of nanowires).