Publications by authors named "Bhandari P"

BACKGROUND : Colorectal polypectomy is operator dependent, with variable rates of complete resection. The currently available assessment tools do not provide specific competency-based evaluation of provider technique. We aimed to validate the Global Polypectomy Assessment Tool (GPAT), a novel competency assessment tool for colorectal polypectomy.

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Background: Computer-aided detection (CADe) systems may increase adenoma detection rate (ADR) during colonoscopy. However, the variable results of CADe effects in different RCTs warrant investigation into factors influencing these results.

Aims: Investigate the different variables possibly affecting the impact of CADe-assisted colonoscopy and its effect on ADR.

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Background: Neurogenic vision loss is often a medical emergency. Early evaluation and urgent treatment of the causes is the key to better visual prognosis.

Methods: This was a retrospective cross-sectional study based on hospital records of patients admitted to the Neurology department of Tribhuvan University Teaching Hospital with complain of diminution of vision from April 2023 to March 2024.

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International medical graduates (IMGs) represent a significant portion of the US physician workforce, comprising 25% across all specialties with a strong presence in internal medicine and primary care. However, their representation in plastic surgery remains limited at only 10%. Matching into a US plastic surgery residency is highly competitive for both US medical graduates and IMGs.

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Introduction: Placenta accreta spectrum (PAS) occurs when the placenta is pathologically adherent to the myometrium. An intact retroplacental clear space (RPCS) is a marker of normal placentation. In this study, we investigate use of the FDA-approved iron supplement ferumoxytol for contrast-enhanced MRI of the RPCS in mouse models of normal pregnancy and PAS.

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In Bangladesh, farming serves as a key livelihood, leading to a higher risk of zoonotic diseases due to frequent animal interactions and traditional practices. The study aimed to assess the knowledge, attitudes, and practices of livestock farmers regarding zoonotic disease outbreaks. A cross-sectional study was conducted with 658 livestock farmers from randomly selected regions in Bangladesh from April to June 2024.

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Anthocyanins (ANS) are an appealing substitute to synthetic colorants; but their practical applicability is limited due to low color stability. Copigmentation can improve both complex's color stability as well as intensity. In this study, we examined the interaction of red cabbage ANS with copigments i.

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Background: Breast cancer ranks as the second most prevalent malignancy among women in Nepal. This cancer has a high likelihood of cure, if detected early. Therefore, it is imperative to emphasize awareness and screening for breast cancer in Nepal.

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Article Synopsis
  • There is a notable gap in research regarding the views of sexual and reproductive health (SRH) providers in the South on telehealth abortion services, which this study aims to address.
  • The study uses qualitative data from interviews with 20 providers to identify key themes related to the importance and challenges of telehealth abortion, including barriers for patients and clinics, as well as influences from the political climate.
  • Findings suggest that while telehealth abortion can help overcome patient-specific barriers and support clinic operations, political factors and staff reluctance significantly impact the prioritization and implementation of such services in Southern clinics.
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Background: Dermoid cysts result from embryonic fusion anomalies, with intracranial dermoid cysts being rare (0.1-0.7% of intracranial tumors).

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Corticosteroid-induced psychosis is rare and less reported in children compared to adults. However, psychosis is considered a severe adverse effect of corticosteroids in pediatric nephrotic syndrome. Steroid-induced psychosis is dose-dependent and should be treated by tapering the dose of steroids and usually initiating an atypical antipsychotic.

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  • The study investigates how using small datasets to select an optimal cutoff score for the Patient Health Questionnaire-9 (PHQ-9) can lead to inaccurate results.
  • Researchers evaluated whether data-driven methods for cutoff selection resulted in scores that were significantly different from the true population optimal score and if these methods produced biased accuracy estimates.
  • Findings showed that many small studies frequently failed to identify the correct optimal cutoff score, particularly in smaller samples, leading to an overestimation of test sensitivity.
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Background: After an increase of central line-associated bloodstream infections (CLABSIs) at our community hospital in 2021, a case-control study suggested that patients with CLABSIs were 3.0 times more likely to have missed daily chlorhexidine gluconate (CHG) bathing than patients without CLABSIs.

Objective: To increase the rate of daily CHG bathing in hospitalized patients with central lines and subsequently reduce the number of CLABSIs.

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  • Rathke's cleft cysts (RCCs) are benign lesions linked to the pituitary gland and can occasionally mimic more common pituitary tumor complications like apoplexy, even though this happens rarely.
  • In a case study, a 30-year-old male with headaches and vomiting had an RCC that was surgically treated, leading to its resolution and requiring ongoing thyroid hormone replacement.
  • The report highlights the necessity of including RCCs in the diagnoses of pituitary lesions, especially when hemorrhage is present, as surgical intervention has positive outcomes.
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Distal radius fractures are common and vary based on their fracture pattern. Fractures distal to the watershed line are called rim fractures or marginal fractures. In addition to challenges already faced when treating distal radius fractures at other sites, rim fractures pose particular challenges in proper identification, reduction, and stabilization.

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Zone 2 of the hand, which stretches from the region between the A1 pulley at the distal palmar crease to the insertion of the FDS tendon at the end of the A4 pulley, is notable for its high complication rate following surgery. Many of these complications, such as adhesions, contractures, and tendon rupture, can be avoided through adequate rehabilitation. We document the rehabilitation protocol at Vanderbilt University Medical center, which is characterized by 4 phases.

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  • AI has the potential to improve gastrointestinal endoscopy, but standardized methods are needed for its effective adoption in clinical practice.
  • The QUAIDE Explanation and Checklist was created by a panel of 32 experts to provide guidelines for designing and reporting AI studies in this field.
  • Consensus was achieved on 18 recommendations across key areas including data collection, outcome reporting, experimental setup, and result presentation, aiming to enhance research consistency and facilitate the use of AI in clinical settings.
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Introduction And Importance: Gorham syndrome, or Gorham-Stout disease, is a rare disorder characterized by spontaneous and persistent bone resorption without any known cause, leading to severe complications [2]. The clinical presentation of this condition varies widely, complicating efforts in diagnosis and treatment. In our case report, we present the story of an 88-year-old woman who bravely and gracefully faced the challenges caused by Gorham syndrome.

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Acquisition of specialized cellular features is controlled by the ordered expression of transcription factors (TFs) along differentiation trajectories. Here, we find a member of the Onecut TF family, ONECUT3, expressed in postmitotic neurons that leave their Ascl1/Onecut1/2 proliferative domain in the vertebrate hypothalamus to instruct neuronal differentiation. We combined single-cell RNA-seq and gain-of-function experiments for gene network reconstruction to show that ONECUT3 affects the polarization and morphogenesis of both hypothalamic GABA-derived dopamine and thyrotropin-releasing hormone (TRH) glutamate neurons through neuron navigator-2 (NAV2).

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Background And Objectives: An external ventricular drain (EVD) placement is a commonly performed life-saving procedure. Its accidental pullout can occur in complex environments, patient care, and positioning, which leads to significant morbidity. The method of EVD fixation and pullout rates is sparsely described in the literature, and there exists a wide variation among the techniques practiced for fixation.

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Article Synopsis
  • Diabetes insipidus is a condition marked by excessive urine production and intense thirst, as seen in a 49-year-old man with symptoms lasting 3 months.
  • He was diagnosed with partial nephrogenic diabetes insipidus due to his inability to concentrate urine and a poor response to desmopressin.
  • Additionally, his recurrent low potassium levels led to the diagnosis of Gitelman syndrome, and with increased fluid intake and potassium supplementation, his symptoms improved, showing potential reversibility of the condition.
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We have studied the impact of nanowire alignment and measurement direction at the percolation threshold on the effective resistance () of two-dimensional (2D) films. This helps us to analyze the effect of anisotropy on the conductivity and transmittance of the nanowire-based network characterized by the disorder parameter (). These optoelectronic properties are determined for systems with monodisperse and bimodal length distribution (a combination of two fixed lengths of nanowires).

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  • The study explores the use of computer-aided diagnosis (CADx) in the resect-and-discard strategy for the optical diagnosis of diminutive polyps during colonoscopy, aiming to improve diagnosis and reduce unnecessary pathology assessments.
  • It involved a systematic review of existing research to analyze the effectiveness of CADx systems compared to traditional histology for small polyps (≤5 mm), including comparisons of CADx-assisted and unassisted methods.
  • The meta-analysis included 11 studies with a total of 7400 polyps examined, highlighting the potential benefits and harms of using CADx in terms of accurate diagnosis and avoidance of false positives/negatives.
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