Publications by authors named "Bhakti I Zakarauskas-Seth"
Article Synopsis
- Epicardial adipose tissue (eAT) is an active fat layer linked to heart health and diseases, but research is limited due to lack of animal models.
- Researchers found a type of fat in zebrafish that acts like beige adipose tissue, which is unique for a species typically thought to have only white fat.
- The zebrafish eAT shows higher expression of genes related to heart function and lower signs of obesity and inflammation compared to those in humans, providing insights into how eAT changes with age in humans.
Aims: Dysregulated immune response contributes to inefficiency of treatment strategies to control hypertension and reduce the risk of end-organ damage. Uncovering the immune pathways driving the transition from the onset of hypertensive stimulus to the manifestation of multi-organ dysfunction are much-needed insights for immune targeted therapy.
Methods And Results: To aid visualization of cellular events orchestrating multi-organ pathogenesis, we modelled hypertensive cardiovascular remodelling in zebrafish.