Biomimetic 3D Prototyping of Hierarchically Porous Multilayered Membranes for Enhanced Oil-Water Filtration.

This study introduces a biomimetic approach to 3D printing multilayered hierarchical porous membranes (MHMs) using Direct Ink Writing (DIW) technology. Fabricated through a fast layer-by-layer printing process with varying concentrations of pore-forming agents, the produced MHMs mimic the hierarchical pore structure and filtration capabilities of natural soil systems. As a result, the 3D-printed MHMs achieved an impressive oil rejection rate of 99.

A single-centre retrospective evaluation of potential drug-drug interactions in breast cancer patients undergoing CDK 4/6 inhibitors chemotherapy.

Introduction: The utilization of CDK4/6 inhibitors has led to compromised survival rates for breast cancer patients. Consequently, certain treatment aspects, involving adherence and drug-to-drug interactions, are gaining prominence. To develop chemotherapy regimens that are both effective and efficient, our main objective was to thoroughly characterize the drug-drug interactions that occur between cyclin-dependent kinase inhibitors and concurrently prescribed medications in hospitalized breast cancer patients.

Enhancing semantic segmentation for autonomous vehicle scene understanding in indian context using modified CANet model.

Recent advancements in artificial intelligence (AI) have increased interest in intelligent transportation systems, particularly autonomous vehicles. Safe navigation in traffic-heavy environments requires accurate road scene segmentation, yet traditional computer vision methods struggle with complex scenarios. This study emphasizes the role of deep learning in improving semantic segmentation using datasets like the Indian Driving Dataset (IDD), which presents unique challenges in chaotic road conditions.

Neurodevelopmental outcomes after infant heart surgery for congenital heart disease: a hospital-based multicentre prospective cohort study from India.

Background: Neurodevelopmental disability is a common long-term concern following surgery for congenital heart disease (CHD). Little information is available from low-resource environments where the majority of children with CHD are born. Several challenges in the CHD care continuum exist in such environments.

Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos.

Light sheet fluorescence microscopy (LSFM) has emerged as a transformative imaging technique in the study of drug delivery and embryonic development, offering high-resolution, real-time visualization with minimal phototoxicity. This review examines the application of LSFM in tracking drug pharmacokinetics, tissue-specific targeting, and drug efficacy during critical phases of embryonic development. Recent advancements in fluorescent labeling and machine learning integration have enabled more precise monitoring of drug release, distribution, and interaction with developing tissues.

Past and future of cytoplasmic male sterility and heterosis breeding in crop plants.

Plant breeding needs to embrace genetic innovations to ensure stability in crop yields under fluctuating climatic conditions. Development of commercial hybrid varieties has proven to be a sustainable and economical alternative to deliver superior yield, quality and resistance with uniformity in a number of food crops. Cytoplasmic male sterility (CMS), a maternally inherited inability to produce functional pollen, facilitates a three-line system for efficient hybrid seed production strategies in crops.

Electrochemical Deconstruction of Waste Polyvinylidene Chloride (PVDC) to Value-Added Products in Batch and Flow.

Chlorinated polymers have made enormous contributions to materials science and are commercially produced on a large scale. These chlorinated polymers could be recycled as chlorine sources to efficiently produce valuable chlorinated compounds owing to their facile release of HCl. Although the thermal stability of PVDC is low compared to PVC, this can be advantageous in terms of easy and fast dehydrochlorination.

Self-esteem and Locus of Control as Predictors of Academic Achievement: A Study Among Graduate Students.

Background: Earlier researchers have explored the individual impacts of locus of control and self-esteem on academic as well as nonacademic success. But limited attention was given to their interplay within a university context. By integrating these variables into a unified framework, a more comprehensive understanding of the learning processes of university students can be achieved, which can further help in developing strategies to improve the overall learning outcome and come out as successful individuals.

Efficient regeneration protocol for producing true-to-type oil palm ( (jacq.) through somatic embryogenesis from immature male inflorescence.

Producing homogeneous planting material in oil palm poses a significant challenge, which can be addressed through somatic embryogenesis. This study successfully achieved somatic embryogenesis using immature male inflorescence from Tenera hybrid. Modified Eeuwens medium yielded better results than the Murashige and Skoog (MS) and CHU (N6) media when supplemented with 2,4-D, picloram and α-naphthaleneacetic acid (NAA).

MythicVision: a deep learning powered mobile application for understanding Indian mythological deities using weight centric decision approach.

Indian mythology is a treasure trove of divine tales, yet a gap in understanding still exists between foreign tourists and the rich cultural heritage of Indian deities. To address the problem, this paper presents a deep learning-driven mobile application named "MythicVision" designed to help foreign tourists better understand India's rich cultural heritage by recognizing and interpreting images of Indian mythological deities. At first, four state-of-the-art deep models have been trained and evaluated on a custom in-house dataset consists of 10,970 images of various Indian deities sourced from both natural scene and web images.

Computed tomography coronary angiography as an alternative to invasive coronary angiography in preoperative evaluation for mitral surgery.

Objective: The aim of this study was to assess the effectiveness of non-invasive coronary computed tomography angiography (CTA) as an alternative to traditional invasive coronary angiography (ICA) for preoperative evaluation of low risk patients with an indication for non-emergent mitral surgery and to assess any difference in adverse outcomes from this strategy.

Methods: This was a retrospective cohort study from a single center with data collected from July 2014 - June 2020 for 1576 patients undergoing mitral valve surgery of all etiologies - excluding patients requiring coronary artery bypass surgery. We performed a 1:2 propensity score matching for patients evaluated with CT (n=345) to those evaluated with ICA (n=602).

Development and validation of a UHPLC-MS/MS method for the quantitative analysis of trans-ISRIB in human plasma.

The integrated stress response (ISR) is a cellular defense mechanism activated under stress conditions. When the ISR is activated, it slows the production of proteins, the building blocks that cells need to function. Trans-integrated stress response inhibitor (trans-ISRIB) is a compound that can reverse the effects of ISR activation, showing promise for treating neurodegenerative diseases.

Optimizing the production and efficacy of antimicrobial bioactive compounds from in combating multi-drug-resistant pathogens.

Background: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of bioactive compounds.

Methods: Soil samples were collected from local regions, processed, and analysed for Streptomyces strains isolation using morphological characteristics and molecular identification through 16S rRNA gene PCR assay.

Cinnamaldehyde impacts key cellular signaling pathways for induction of programmed cell death in high-grade and low-grade human glioma cells.

Objective: Primary tumors of the brain and a large percent of malignant brain tumors are gliomas. Gliomas comprise high-grade gliomas like glioblastoma multiforme (GBMs), many of which have mutation in the tumor suppressor p53 gene and low-grade gliomas (LGGs). LGGs can progress to GBMs due to various factors.

Radiomorphometric Parameters in Mandibular Panoramic Radiographs of Hypothyroid Patients: A Cross-Sectional Study.

Purpose: Thyroid hormones have a catabolic effect on bone mineral homeostasis. Hypothyroid patients have shown changes in bone mineral density with increased risk for osteoporosis and bone fractures. Radiomorphometric parameters on panoramic images are good indicators of bone mineral density.

Quantum leap in the diagnosis of oral potentially malignant disorders - A review of literature.

Early diagnosis of oral potentially malignant disorders (OPMDs) can bring about considerable improvement in reducing the statistics related to morbidity and mortality associated with oral cancer. The objective of this review was to summarize advanced diagnostic aids used for OPMDs. Pubmed, Embase, and Cochrane Central Register of Controlled Trials electronic databases from 1969 to 2022 focus on advanced diagnostic techniques for potentially malignant disorders.

Morphometric evaluation of middle ear anatomical structures using full volume (12 × 9) CBCT scans: A retrospective study in Navi Mumbai.

Introduction: The tympanic cavity contains three tiny bones, the malleus, incus, and stapes, which have a fundamental role in the transmission of sound. Recent research emphasizes the use of CBCT for the anatomic study of the temporal bone. The information about middle ear anatomy on CBCT scans is meager; hence, this retrospective study was conducted to identify and determine the various morphometrical parameters of the malleus using CBCT which can be helpful during reconstructive procedures for the otologic surgeon.

Muscle biochemistry and residue accretion in male Oreochromis niloticus fries administered therapeutic, subtherapeutic and overdoses of dietary oxytetracycline.

Oxytetracycline (OTC), an approved antibiotic for aquaculture, is under strict control and regulatory endeavour. This study compared the effects of oral administration of graded doses of OTC comprising the therapeutic (80 mg/kg biomass/day), subtherapeutic (40 mg) and overdoses (240, 400 and 800 mg) in male Nile tilapia Oreochromis niloticus fries (0.64 ± 0.

Institution of cardiopulmonary bypass in an awake patient for resection of isolated intrathoracic right subclavian artery aneurysm causing near total compression of the trachea.

The subclavian artery's intrathoracic segment is a rare peripheral artery aneurysm site. Common causes are atherosclerosis, trauma, vasculitis, and infection. Subclavian artery aneurysms have a higher propensity for rupture, thrombosis, embolization, and compression of surrounding structures, thus necessitating urgent surgical care.

Efficacy of Bilastine, Dextromethorphan, and Phenylephrine Syrup in Patients With Dry Cough: A Phase 3 Randomised Trial.

Background Cough in common cold is often associated with rhinorrhoea and nasal congestion, requiring treatment with a cough suppressant, decongestant, and antihistamine. Bilastine is a non-sedating antihistamine, a preferred option over sedating antihistamines. A combination of bilastine, dextromethorphan, and phenylephrine is expected to provide non-sedating treatment for cough associated with a common cold or allergy.

Biosafety and Withdrawal Period of In-Feed Administered Antiparasitic Drug Emamectin Benzoate in Cirrhinus mrigala (Hamilton, 1822).

Parasitic infestations are one of the most economically important disease conditions in the Indian major carps including mrigal, Cirrhinus mrigala. This study reported the biosafety and tissue withdrawal of in-feed administered antiparasitic drug, emamectin benzoate (EMB). To evaluate the biosafety of the drug, behaviour, growth and tissue changes in Cirrhinus mrigala was recorded the following in-feed administration of EMB up to 10 times (T1-50 μg kg fish day (1×), T2-125 μg kg fish day (2.

Looking back into the Hepatitis C Virus epidemic dynamics from Unnao, India through phylogenetic approach.

Viral hepatitis is a major public health challenge. Hepatitis C Virus (HCV) infection causes the progressive liver damage. A surprisingly high number of individuals tested positive for HCV infection during the Unnao Human Immunodeficiency Virus (HIV) outbreak investigation in 2017-2018 (more than 90% of the people living with HIV were from the Premganj township and Chakmeerapur village of the district in the northern State of Uttar Pradesh).

Development, review, and activation of thoracic oncology investigator-initiated trials.

Background: Investigator-initiated trials (IITs) may address important biological and clinical questions that may not be prioritized by pharmaceutical sponsors. However, little is known about the process by which IIT proposals are evaluated and activated.

Methods: We performed a retrospective study of IIT concepts submitted through the Academic Thoracic Oncology Medical Investigators Consortium (ATOMIC), which comprises 13 institutions in the U.