A novel ORF1a-based SARS-CoV-2 RT-PCR assay to resolve inconclusive samples.

Background: India bears the second largest burden of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. A multitude of reverse transcription polymerase chain reaction (RT-PCR) detection assays with disparate gene targets, including automated high-throughput platforms, are available. Varying concordance and interpretation of diagnostic results in this setting can result in significant reporting delays, leading to suboptimal disease management.

Rab11a drives adhesion molecules to the surface of endometrial epithelial cells.

Study Question: Is Rab11a GTPase, a regulator of intracellular trafficking, of significance in endometrial functions?

Summary Answer: Rab11a is an important component of the cascades involved in equipping the endometrial epithelium (EE) with 'adhesiveness' and 'cohesiveness'.

What Is Known Already: Cell adhesion molecules (CAMs) have been investigated extensively for modulation in their endometrial expression during the peri-implantation phase. However, the mechanisms by which CAMs are transported to the EE surface have not received the same attention.