An international survey on the knowledge, attitudes and clinical patterns of use of medical cannabis for cancer care: The TASMAN study.

Background: Medical cannabis (MC) has gained traction in oncology for managing cancer-related symptoms, but its integration faces challenges due to limited evidence, inconsistent guidelines, and varied legal frameworks.

Methods: The TASMAN study aimed to assess the knowledge, attitudes, and practices of oncologists and palliative care providers globally regarding MC use in cancer care. A survey of healthcare providers from diverse regions and income levels was conducted.

A scoping review on efficacy and safety of medicinal plants used for the treatment of diarrhea in sub-Saharan Africa.

Background: In sub-Saharan Africa (SSA), significant morbidity and mortality have been linked to diarrhea, which is frequently caused by microorganisms. A rise in antimicrobial-resistant pathogens has reignited the search for alternative therapies. This scoping review aims to map the literature on medicinal plants in relation to their anti-diarrheal potential from SSA.

Spatial autocorrelation and hotspot analysis of natural radionuclides to study sediment transport.

Tracking sediment movement is typically done with artificial radionuclides. However, this can be environmentally harmful and does not allow for sediment classification. Naturally occurring radionuclides are consequently offered as an alternative.

Indoor Radon Levels in Homes and Schools in the Western Cape, South Africa-Results from a Schools Science Outreach Initiative and Corresponding Model Predictions.

We describe a school science outreach initiative that introduced learners to applied nuclear physics research by means of a two-day workshop that involved learners and teachers from 5 schools in the Western Cape province of South Africa. During this workshop, the participants were introduced to the naturally occurring, inert, colorless, and tasteless radioactive gas radon (Rn). During the first day of the workshop, the participants were informed about the detrimental health impacts of inhaling radon and its daughter radionuclides and were shown how indoor radon activity concentrations can be measured using the electret ion chamber (EIC) technology.

Estimating geothermal and background radiation hotspots from primordial radionuclide concentrations in geology of South Africa.

Naturally occurring radionuclides are the main generator of geothermal energy in the Earth's crust and mantle. The generated energy is consequently directly proportional to the concentrations of the three main naturally occurring radionuclides (uranium, thorium and potassium), which are primordial in origin. Concentrations of these naturally occurring radionuclides were extracted for all the different geological rock units in South Africa.

Assessment of Thermal and Hydrolytic Stabilities and Aqueous Solubility of Artesunate for Formulation Studies.

For the purpose of establishing the optimum processing parameters and storage conditions associated with nanolipid formulations of the artemisinin derivative artesunate, it was necessary to evaluate the thermal stability and solubility profiles of artesunate in aqueous solutions at various temperatures and pH. The effect of increased temperature and humidity on artesunate was determined by storing samples of the raw material in a climate chamber for 3 months and analyzing these by an established HPLC method. Artesunate remained relatively stable during storage up to 40°C ± 0.

An automated drift correction method for in situ NaI(Tl)-detectors used in extreme environments.

Gamma-ray detection systems are exposed to extreme environments during in situ measurements and the NaI(TI)-detectors in these systems are frequently subjected to significant temperature fluctuations. Several elements within these detectors are sensitive to temperature deviations, which ultimately causes a drift in gamma-ray spectra. This study aimed to determine the relationship between temperature deviation and spectrum drift and found a linear relationship over a wide range of energies.

Effect of the Elemental Content of Shells of the Bivalve Mollusks () from Saldanha Bay (South Africa) on Their Crystallographic Texture.

A both wild and farmed mussels in natural conditions, anthropogenic inputs are usually reflected in the increase of the content of specific elements. To determine the possible effect of the elemental patterns of farmed and wild mussels () collected in the Saldanha Bay area (South Africa) on the crystallographic texture of the shells, the content of 20 elements in shells and 24 in the soft tissue of mussels was determined by neutron activation analysis. The crystallographic texture of mussel shells was analyzed using time-of-flight neutron diffraction.

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is characterized by acute clinical pathologies, including various coagulopathies that may be accompanied by hypercoagulation and platelet hyperactivation. Recently, a new COVID-19 phenotype has been noted in patients after they have ostensibly recovered from acute COVID-19 symptoms. This new syndrome is commonly termed Long COVID/Post-Acute Sequelae of COVID-19 (PASC).

Estimating indoor radon concentrations based on the uranium content of geological units in South Africa.

Very few studies have been done on radon in South Africa, even though South Africa holds nearly a tenth of the global uranium deposits. This study aimed to map and estimate the radon risk for South Africa, and to identify potential hotspots. In this study, the uranium content of the different types of rock was determined and uranium concentrations in geological units were then projected.

MinION 16S datasets of a commercially available microbial community enables the evaluation of DNA extractions and data analyses.

New advances in sequencing technology and bioinformatics analysis tools have significantly supported the culture-independent analysis of complex microbial communities associated with environmental, plant, animal and human samples. However, previous work has shown that DNA extraction can have a major influence in the community profile. As such there is a constant need for new methods to efficiently and rapidly prepare and analyze DNA for microbiome research, especially in the case new and emerging technology like the Oxford Nanopore Technologies (ONT) MinION.

The Anthropogenic Impact on Indoor Radon Concentrations for Secunda, Mpumalanga Province, South Africa.

Secunda is a town built amid the coalfields of the Mpumalanga province of South Africa. Surrounding the town are 11 coal-fired plants (CFPs) contributing around 59% of the country's energy needs. It is also home to Sasol Synfuels, which produces synthetic gas through coal gasification and natural gas reforming.

Associations of Pretreatment Physical Status Parameters with Tolerance of Concurrent Chemoradiation and Survival in Patients with Non-small Cell Lung Cancer.

Objective: The aim of this study was to evaluate associations between pretreatment physical status parameters and tolerance of concurrent chemoradiation (cCHRT) and survival among patients with stage III non-small cell lung cancer (NSCLC).

Methods: A retrospective cohort study was conducted among patients with stage III NSCLC who had received cCHRT between 2006 and 2015. Multivariate independent associations were analysed between the pretreatment parameters age, Charlson comorbidity index, World Health Organization performance status (WHO performance status), body mass index (BMI), fat-free mass index (FFMI), maximal handgrip strength, forced expiratory volume in one second and carbon monoxide lung diffusion capacity on the one hand with tolerance of cCHRT (defined as a received radiation dose at least equal to the prescribed radiation dose) and survival on the other hand.

Outcomes of newborn hearing screening at an academic secondary level hospital in Johannesburg, South Africa.

Background: The Health Professions Council of South Africa (HPCSA) issued early hearing detection and intervention guidelines, which has universal newborn hearing screening (UNHS) as one of the important goals. Despite established evidence of the importance of UNHS globally, there has been no mandated formalised and standardised implementation as yet in South Africa.

Objectives: The aim of this study was to describe the outcomes of newborn hearing screening (NHS) in an academic secondary level hospital in Johannesburg, South Africa.

Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency.

Aims: The risk of cardiovascular events in patients with Rheumatoid Arthritis (RA) is disproportionately heightened as a result of systemic inflammation. The relative effect of autoimmune-associated citrullination on the structure and thrombotic potential of fibrin(ogen) remains unknown. We therefore compared indices of vascular function, inflammation, coagulation and fibrin clot composition in RA patients with healthy controls and evaluated parameter association with disease presence.

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19.

Progressive respiratory failure is seen as a major cause of death in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection. Relatively little is known about the associated morphologic and molecular changes in the circulation of these patients. In particular, platelet and erythrocyte pathology might result in severe vascular issues, and the manifestations may include thrombotic complications.

INDOOR RADON MEASUREMENTS FOR THE SOUTH AFRICAN WEST COAST PENINSULA.

Granite commonly contains high concentrations of uranium, with consequent high exhalation of radon. The geology of the West Coast peninsula of South Africa is dominated by granite, and a recent article predicted potentially high indoor radon concentrations in this region's two largest towns, Vredenburg and Saldanha. This research aimed to measure indoor radon levels in these towns.

Methylene blue analogues: In vitro antimicrobial minimum inhibitory concentrations and in silico pharmacophore modelling.

It has been shown that methylene blue has antimicrobial properties although few studies have determined its minimum inhibitory concentration (MIC), which is the gold standard used to measure antimicrobial activity. The exact antimicrobial mode of action of methylene blue is still unclear and to our knowledge no pharmacophore model has yet been created to investigate methylene blue's mode of action. The aim of this study was to determine the MIC of methylene blue and a number of its analogous against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica and Candida albicans, and to use these data to develop and validate a common feature pharmacophore model.

Students' voices: assessment in undergraduate clinical medicine.

Introduction: the perception exists among students that not all clinical assessments in undergraduate medical programmes are of high quality. 'Student voice' is a term used to describe how students feel about and experience their education in a safe and controlled environment. This study aimed to investigate the opinions and experiences of medical students at the University of the Free State on the quality of assessment in the clinical phase of medicine.

Quality assessment in undergraduate medical training: how to bridge the gap between what we do and what we should do.

Introduction: the outcome of the undergraduate medical training programme in South Africa is to produce competent medical doctors who can integrate knowledge, skills and attitudes relevant to the South African context. Training facilities have a responsibility to ensure that they perform this assessment of competence effectively and defend the results of high-stakes assessments. This study aimed to obtain qualitative data to suggest practical recommendations on best assessment practices to address the gaps between theoretical principles that inform assessment and current assessment practices.

Assessment practices in undergraduate clinical medicine training: What do we do and how we can improve?

Background: Assessment should form an integral part of curriculum design in higher education and should be robust enough to ensure clinical competence.

Aim: This article reports on current assessment practices and makes recommendations to improve clinical assessment in the undergraduate medical programme at the University of the Free State.

Methods: A descriptive cross-sectional study design was used.

The Central Role of Acute Phase Proteins in Rheumatoid Arthritis: Involvement in Disease Autoimmunity, Inflammatory Responses, and the Heightened Risk of Cardiovascular Disease.

Rheumatoid arthritis (RA) is an autoimmune disease of complex etiopathogenic origin and traditionally characterized by chronic synovitis and articular erosions. Furthermore, there is strong evidence that infectious agents, including those that become dormant within the host, play a major role in much of the etiology of RA and its hallmark of inflammation. A combination of genetic predisposition, environmental exposure, and presence of infectious agents may therefore lead to a loss of immune tolerance to citrullinated proteins, which present as self-antigens to the human immune system.

A framework to benchmark the quality of clinical assessment in a South African undergraduate medical programme.

Background: The outcome of the undergraduate medical programme is to produce clinically competent health care providers relevant for the South African context. Educational institutions find it hard to ensure the quality of assessments where competency must be assessed. This study aimed to compile an assessment framework that can be used to benchmark current assessment practices in the clinical phase of the undergraduate medical programme where competency must be certified.

Handgrip weakness, low fat-free mass, and overall survival in non-small cell lung cancer treated with curative-intent radiotherapy.

Background: Assessment of handgrip strength and fat-free mass provides quick and objective information on muscle performance and mass that might complement subjective World Health Organization Performance Status (WHO PS). We investigated to what extent the presence of pre-treatment handgrip weakness and low fat-free mass index (FFMI) provides additional prognostic information on top of well-established prognostic factors (including WHO PS) in non-small cell lung cancer (NSCLC) patients selected for curative-intent (chemo)radiation.

Methods: Prospectively, patients with early and locally advanced NSCLC (stages I-III) treated with (chemo)radiation were enrolled.