[Upgrading efficiency and safety of combined antihelicobacterial treatment of ulcer patients using modern clinicopharmacological approaches].

Therapeutic monitoring of ranitidine and omeprasol using automatic analyser REMEDi HS Drug Profiling System (Bio-Rad, USA) was performed in 120 patients with morphologically verified ulcer associated with Helicobacter pylori. The addition of antibacterial drugs elevated concentration of blood ranitidine, omeprasol being stable. The highest therapeutic effectiveness was achieved with combination of ranitidine plus metronidasol and jozamycin as well as omeprasol plus metronidasol and claritromycin.

[Josamycin combination with ranitidine in therapy of gastroduodenal ulcer: clinical efficiency].

Efficacy of a novel eradication treatment with ranitidine, trichopol and jozamycin was compared to that of the standard three-component therapy and monotherapy with ranitidine in 76 patients with exacerbation of gastric and duodenal ulcer. Therapeutic monitoring of ranitidine was performed. In relation to healing of ulcer defect and eradication of Helicobacter pylori, jozamycin is not less effective and more safe than standard three-component therapy.