Publications by authors named "Beza Leulseged Ayalew"
Background: Prader-Willi syndrome is a complex multisystem disorder due to the absent expression of paternally active genes in the Prader-Willi syndrome-critical region on chromosome 15 (15q11.2-q13). The main clinical features are hyperphagia (which frequently results in early-onset obesity), hypogonadism, developmental delays, typical behaviors (such as obsessive-compulsive tendencies, tantrums, perseveration, insistence on sameness, and rigidity), and distinctive facial features.
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- Severe insulin resistance is characterized by an insulin requirement over 2 units per kg of body weight and is uncommon in diabetics.
- Common causes include severe insulin resistance syndromes, medications, endocrine disorders, and other factors, while the specific case described involved pseudo-resistance due to improper insulin use.
- Proper assessment is essential for patients needing high doses of insulin to rule out issues like injection technique, medication adherence, or storage problems.