Clinical Characteristics of Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy.

Juvenile nasopharyngeal angiofibroma (JNA) is a benign vascular tumor occurring in young males. Treatment of JNA is a complex procedure, especially in advanced cases with a high risk of major complications. We report the clinical, radiological and histological specialties of a rare case of recurrent JNA 3 years after radiation therapy in an 18-year-old boy.

An unusual mass of nasal cavity: recurrent glomangiopericytoma.

Hemangiopericytomas are rare tumors of sinonasal region. In this article, we described a case of recurrent mass in right nasal cavity which presented with nasal obstruction and intermittent epistaxis. Patient had a surgical history on the same nasal region without any histopathological document.

Morphological evaluation of parathyroid adenomas and immunohistochemical analysis of PCNA and Ki-67 proliferation markers.

Objective: Parathyroid adenomas are the most common cause of primary hyperparathyroidism. Biological studies have shown that parathyroid adenomas are monoclonal proliferations. Up to date, five cell types have been identified in normal parathyroid tissues; chief cells, vacuolated chief cells, dark chief cells, oxyphil cells and transitional oxyphil cells.

Immunohistochemical and morphologic findings in columnar cell lesions of the breast.

Background: Columnar cell lesions (CCLs) with or without atypia frequently coexist with invasive or in situ breast carcinomas. In this study, 39 mastectomy specimens containing CCLs coexisting with invasive carcinomas were retrospectively analyzed for cellular characteristics and structural pattern of CCL neighboring the tumor.

Materials And Methods: The expression of estrogen receptor (ER), progesterone receptor (PR), and p53 antibodies in CCL and coexisting invasive tumors, type of invasive tumor, histopathologic grade, and presence of atypia in CCL have been studied.

Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma.

Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological sections.

HER-2/neu gene codon 655 (Ile/Val) polymorphism in breast carcinoma patients.

Amplification and/or overexpression of HER-2/neu has been reported to be associated with poor prognosis in breast cancer. One single-nucleotide polymorphism at codon 655 indicates a guanine-to-adenine substitution (Ile655Val) in the transmembrane domain-coding region of the HER-2/neu gene reported to be associated with increased risk of breast cancer. However, several studies have shown that this association is controversial.

Intravenous lipoleiomyomatosis of uterus with cardiac extension: a case report.

A case of intravenous leiomyomatosis (IVL) with histological features of a lipoleiomyoma (intravenous lipoleiomyoma) in a 48-year-old woman is reported. The patient, with the tumor located in the uterus and extended up on the right side of the heart through the inferior vena cava, was diagnosed as having a cardiac mass. She displayed symptoms of dyspnea, chest pain due to the cardiac mass, as well as pelvic pain and dysmenorrhea.

Steroid-resistant acute rejections after liver transplant.

Objectives: Liver transplant is the definitive treatment for the end-stage liver disease. Although effective immunosuppressants are available, steroid-resistant acute rejection can be encountered.

Materials And Methods: Between September 2001 and April 2010, 285 adult and pediatric liver transplants were done on 279 patients from deceased donors and living-related donors at our center.

Immunohistochemical FHIT expression still exists in early lesions of basal cell carcinoma.

In this study, we evaluated the expression of Fragile Histidine Triad (FHIT) in basal cell carcinoma (BCC). The FHIT locus was found to be altered in numerous types of cancer [6,7,18,20,22,25,26]. However, we found only one study dealing with FHIT expression in BCC [11].

Management of elderly patients with advanced non-small cell lung cancer in Turkey.

Objective: Non-small cell lung cancer is a disease that affects the elderly. However, most patients older than 70 years are less likely to receive standard therapy than their younger counterparts and the aim of the present study was to determine age-dependent variation in efficacy.

Subjects And Methods: Between 2004-2008, 40 consecutive patients older than 70 years received treatment for advanced non-small cell lung cancer.

p53 expression in pterygium in two climatic regions in Turkey.

Purpose: To assess accumulation of p53 protein in samples of primary pterygium from people living in two different climatic regions in Turkey.

Materials And Methods: Group 1 included 101 pterygium specimens from people in Adana located in southern Turkey. Group 2 included 39 pterygium specimens from people in Ankara, located in the middle of Turkey.

Induction of apoptosis of rabbit corneal endothelial cells by preservative-free lidocaine hydrochloride 2%, ropivacaine 1%, or levobupivacaine 0.75%.

Purpose: To determine and compare the amount of apoptosis and changes in rabbit corneal endothelial cell morphology after intracameral administration of different anesthetic agents.

Setting: Department of Ophthalmology, Baskent University Medical Faculty, Ankara, Turkey.

Methods: Right eyes of 64 Vienna white rabbits were injected intracamerally with preservative-free lidocaine hydrochloride 2%, ropivacaine 1%, levobupivacaine 0.

Pap smear findings in chronic renal failure patients compared with the normal population according to Bethesda 2001.

Dialysis remains the most common treatment for end-stage renal disease (ESRD). Although the increased risk of cancer after renal transplant is well documented, there is less certainty about the risk of cancer in patients treated only with dialysis. From 1997 to 2002, 262 ESRD patients received a Pap test at Başkent University.

Fulminant hepatic failure in children: etiology, histopathology and MDCT findings.

Introduction: The purpose of this study is to determine the etiologies, histopathology and MDCT findings of children with fulminant hepatic failure admitted to our institution.

Materials And Methods: Between June 2004 and November 2006, 15 children with fulminant hepatic failure who underwent MDCT were included retrospectively in this study. Twelve patients had liver biopsies.

Total colonic polyp diameter: a marker for the risk of malignancy?

Background/aims: The correlation of the risk of malignancy with the sum of the diameters of small colonic polyps is unknown, and data regarding this topic are lacking. In this study, the relationship between the sum of the diameters of the total number of colonic polyps and poor histopathologic characteristics was examined.

Methods: A total of 920 neoplastic colon polyps were evaluated in 480 patients.

Diagnostic accuracy of fine-needle aspiration cytology of palpable breast masses: an SROC curve with fixed and random effects linear meta-regression models.

We used various meta-analytic methods to compare 25 studies describing fine-needle aspiration (FNA) cytologic analyses performed from 1984 to 2007 on palpable breast masses. We found that in the 25 studies examined, the sensitivity ranged from 78% to 100%, the specificity ranged from 76% to 100%, and the diagnostic odds ratio (DOR) ranged from 15.83 to 33 198.

Pediatric liver transplant: results of a single center.

Objectives: Liver transplant in the pediatric population has become an accepted treatment modality for children with end-stage liver disease. In this study, we analyze our experiences with pediatric liver transplant at our center.

Materials And Methods: Since September 2001, 8 deceased-donor and 96 living-donor liver transplants have been done in 101 children (mean age, 6.

Acute humoral rejection after kidney transplantation: a report of two cases.

Acute humoral rejection (AHR) should be considered in patients with renal allograft dysfunction that develops at any stage of the post-transplant course. AHR has become increasingly recognized and is now more accurately diagnosed by the use of flow cytometry cross-matching, the identification of C4d deposits shown on renal allograft biopsy, and the assessment of allograft function. Although plasma exchange has been a popular treatment for AHR, other treatment modalities have also been used by transplant centers.

VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value.

Objective: To evaluate the prognostic value of new markers such as VEGF (vascular endothelial growth factor), COX-2 (cyclooxygenase-2), and PCNA (proliferating cell nuclear antigen) and review their differences in expression by histological subtype in patients with renal cell carcinoma (RCC).

Methods: About 99 patients who underwent radical (n = 79) or partial nephrectomy (n = 20) were included in this study. Histopathological specimens from the subjects were retrospectively analyzed immunohistochemically for the presence of VEGF, COX-2, or PCNA.

Liver transplant in an infant with bilateral cystic neuroblastoma complicated by hepatic metastases and life-threatening consumption coagulopathy.

Here we report a patient with stage-4 bilateral cystic adrenal neuroblastomas with disseminated liver metastases and consumption coagulopathy who underwent liver transplant. Our patient was initially diagnosed with infantile hepatic hemangioendothelioma and bleeding into the adrenal glands secondary to consumption coagulopathy (Kasabach-Merritt syndrome). Liver transplant was performed as a life-saving procedure under this diagnosis.

Hepatic parenchymal changes and histologic eosinophilia as predictors of subsequent acute liver allograft rejection.

During the first episode of acute cellular rejection (ACR) after liver transplantation, centrilobular changes in liver biopsy specimens may be possible indicators of subsequent episodes of ACR, early chronic rejection, or acute graft loss. The purpose of this study was to identify differences between the histopathological findings in liver biopsy specimens obtained during the first rejection episode in patients who subsequently developed further episodes of ACR and those who did not. The histopathological findings in 22 patients who had a single episode of acute rejection (group 1) were compared with those in 23 patients who had multiple episodes of acute rejection (group 2).

Unusual spindle cell tumor of thyroid (SETTLE).

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare tumor seen mostly in children and adolescents. It is presumed that it arises from ectopic thymus or remnants of branchial pouches that differentiate along the thymic line. Unusual spindle cell-predominant histology makes this entity difficult to recognize.

Endolymphatic sac papillary tumor: a case report and review.

Endolymphatic sac papillary tumor (endolymphatic sac adenoma, temporal-mastoid bone adenoma or adenocarcinoma, low-grade adenocarcinoma of potential endolymphatic sac origin, aggressive papillary tumor of the temporal bone, Heffner's tumor) is a rare lesion that involves the temporal bone. This tumor usually appears alone, but in 11-30% of afflicted individuals, it is accompanied by von Hippel-Lindau disease. Endolymphatic sac papillary tumors are destructive tumors that exhibit locally aggressive behavior.

[Classic Kaposi's sarcoma of the tongue: a case report].

An 81-year-old male patient presented with a painful mass in the tongue that showed a progressive growth within the past two months. Examination revealed a polypoid mass in the midline of the tongue, purple in color, and 1.5x1.

Small bowel perforation due to metastatic lung squamous cell carcinoma.

Squamous cell cancer of the lung occurs with early dissemination but clinically significant metastases localized to the small bowel are rare. Small bowel metastasis is a fatal complication usually seen in advanced stages of the disease. In the present study, we report a case of a 65-year-old patient who was admitted to the emergency department with acute abdominal pain and during evaluation was found to have squamous cell carcinoma metastasis to small bowel leading to perforation.