Reaction time and incident cancer: 25 years of follow-up of study members in the UK Health and Lifestyle Survey.

Objectives: To investigate the association of reaction time with cancer incidence.

Methods: 6900 individuals aged 18 to 94 years who participated in the UK Health and Lifestyle Survey in 1984/1985 and were followed for a cancer registration for 25 years.

Results: Disease surveillance gave rise to 1015 cancer events from all sites.

IQ in childhood and atherosclerosis in middle-age: 40 Year follow-up of the Newcastle Thousand Families Cohort Study.

Objective: Carotid intima-media thickness (IMT) is a known precursor to coronary heart disease (CHD) and other relevant health outcomes such as stroke and cognitive impairment. In addition, higher childhood intelligence has been associated with lower risk of coronary heart disease events in later life, although the mechanisms of effect are unclear. We therefore examined the association between childhood intelligence and atherosclerosis using carotid IMT as a marker of the atherosclerotic process.

Neuroticism combined with slower and more variable reaction time: synergistic risk factors for 7-year cognitive decline in females.

Objective: Among adults, slower and more variable reaction times are associated with worse cognitive function and increased mortality risk. Therefore, it is important to elucidate risk factors for reaction time change over the life course. Method.

Intelligence in youth and all-cause-mortality: systematic review with meta-analysis.

Background: A number of prospective cohort studies have examined the association between intelligence in childhood or youth and life expectancy in adulthood; however, the effect size of this association is yet to be quantified and previous reviews require updating.

Methods: The systematic review included an electronic search of EMBASE, MEDLINE and PSYCHINFO databases. This yielded 16 unrelated studies that met inclusion criteria, comprising 22,453 deaths among 1,107,022 participants.

Does retirement influence cognitive performance? The Whitehall II Study.

Background: Occupational work involves many factors capable of protecting cognition. The 'disuse' hypothesis suggests that removal of such factors at retirement may increase the risk of cognitive decline.

Objective: To examine whether retirement is significantly associated with cognitive change after adjusting for preretirement cognitive function, personal, social, health and lifestyle factors, work characteristics and leisure activity.

Direct and indirect pathways connecting cognitive ability with cardiovascular disease risk: socioeconomic status and multiple health behaviors.

Objective: To model and test direct and indirect pathways connecting general cognitive ability (g) with cardiovascular disease risk factors, via socioeconomic status (SES) and multiple health behaviors.

Methods: A sample comprising participants in the Health and Lifestyle Survey, a prospective cohort study of a representative sample of U.K.

IQ in late adolescence/early adulthood, risk factors in middle age, and later cancer mortality in men: the Vietnam Experience Study.

Objectives: (i) examine the relation, if any, of pre-morbid IQ scores at 20 years of age with the risk of later cancer mortality; and (ii) explore the role, if any, of potential mediating factors (e.g. smoking, obesity), assessed in middle age, in explaining the IQ-cancer relation.