Publications by authors named "Beverley J Botting"
Article Synopsis
- The study aims to investigate whether children conceived through assisted reproductive technology (ART) have a higher risk of developing Langerhans cell histiocytosis (LCH) compared to the general population.
- After analyzing data from over 118,000 children, it found 8 cases of LCH, which is higher than the expected 3.75 cases, but this result was not statistically significant.
- The research indicated a notable association between increased LCH cases and specific ART methods like intracytoplasmic sperm injection (ICSI), especially in instances of male factor infertility, suggesting more research is needed despite the overall low risk.
Article Synopsis
- The study investigates the connection between in vitro fertilization (IVF) treatment and the risk of hypertensive disorders during pregnancy.
- Researchers analyzed data from 1,465,893 pregnancies, comparing births from IVF-treated women to those from fertile women, focusing on treatment factors like oocyte source and embryo state.
- Findings suggest that women undergoing IVF with autologous-fresh embryos do not have a higher risk of hypertensive disorders compared to their fertile counterparts.
Objective: To investigate the risks of ovarian, breast, and corpus uteri cancer in women who have had assisted reproduction.
Design: Large, population based, data linkage cohort study.
Setting And Participants: All women who had assisted reproduction in Great Britain, 1991-2010, as recorded by the Human Fertilisation and Embryology Authority (HFEA).
Background: Accurate population-based data are needed on the incidence of cancer in children born after assisted conception.
Methods: We linked data on all children born in Britain between 1992 and 2008 after assisted conception without donor involvement with data from the United Kingdom National Registry of Childhood Tumours to determine the number of children in whom cancer developed before 15 years of age. Cohort cancer rates were compared with population-based rates in Britain over the same period, with stratification for potential mediating and moderating factors, including sex, age at diagnosis, birth weight, singleton versus multiple birth, parity, parental age, type of assisted conception, and cause of parental infertility.