Creatine supplementation research fails to support the theoretical basis for an effect on cognition: Evidence from a systematic review.

Creatine supplementation has been put forward as a possible aid to cognition, particularly for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However, previous narrative reviews have only provided limited support for these claims. This is despite the fact that research has shown that creatine supplementation can induce increased brain concentrations of creatine, albeit to a limited extent.

Evaluation of possible role of fluoride in pathogenesis of oral submucous fibrosis: A pilot study.

Background: Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Although areca nut chewing is an established risk factor, its low prevalence among nut chewers indicates additional factors likely facilitates pathogenesis. We recently demonstrated high fluoride levels in smokeless tobacco products and hypothesized a potential pathological role of fluoride in OSMF.

The effect of particle size on oral bioavailability and bioaccessibility of soil Ni from different sources.

The goal of the work was to contribute to a unified approach to assessing the risk to human health of soil ingestion, for contaminated sites with elevated [Ni]. Robust relationships between in vitro bioaccessibility and in vivo bioavailability of Ni in various soils, with mechanistic understanding, would enable site-specific assessments of human exposure through soil ingestion. Four soils (three ultramafic Brunisols with geogenic Ni and one Organic soil with anthropogenic Ni) were sieved into PS < 10 μm, 10-41 μm, 41-70 μm, 70-105 μm, 105-150 μm, and 150-250 μm, the [Ni] for which ranged from 560 to 103000 mg/kg.

Response addition is more protective of biogeochemical cycles of carbon and phosphorus compared to concentration addition.

In soils, enzymes are crucial to catalyzing reactions and cycling elements such as carbon (C), nitrogen (N), and phosphorus (P). Although these soil enzymes are sensitive to metals, they are often disregarded in risk assessments, and regulatory laws governing their existence are unclear. Nevertheless, there is a need to develop regulatory standards for metal mixtures that protect biogeochemical cycles because soil serve as a sink for metals and exposures occur as mixtures.

Phytotoxicity effect concentrations (ECx) for Ce, Nd and Eu added to soil relative to total and bioaccessible soil REE concentrations, and tissue REE accumulations.

Toxicity thresholds (EC) for radish, tomato, and durum wheat growth endpoints (shoot length, shoot mass, root length) to Ce, Nd or Eu added to a black organic soil were determined from 14-day dose-response growth assays. EC expressed as total soil [REE] had a more than twenty-fold range, from 337 mg/kg to more than >8000 mg/kg. Averaged over all REEs and endpoints, durum wheat was more tolerant than radish and tomato; and averaged over all endpoints, Eu appeared to be the most phytotoxic of the three REEs.

Derivation of a Ni bioaccessibility value for screening-level risk assessment of Ni substances in ingested materials including soils.

The objective of the present study was to derive a Ni bioaccessibility value for screening-level risk assessment of Ni substances in ingested materials including soils where multiple Ni substances are expected but not definitively identified. Broad ranges of Ni mass loading and dissolution time of a simple gastric assay were applied to pure Ni substances (removing the confounding factors of soil constituents on dissolution), thus broadening the applicability of the conclusions. The data were also used to support current knowledge of 'read across' for Ni substances.

Development of physical employment standards of specialist paramedic roles in the National Ambulance Resilience Unit (Naru).

Aim: To develop evidence-based role-specific physical employment standards and tests for National Ambulance Resilience Unit (NARU) specialist paramedics.

Methods: Sixty-two (53 men, 9 women) paramedics performed an array of (1) realistic reconstructions of critical job-tasks (criterion job performance); (2) simplified, easily-replicable simulations of those reconstructions and; (3) fitness tests that are portable and/or practicable to administer with limited resources or specialist equipment. Pearson's correlations and ordinary least products regression were used to assess relationships between tasks and tests.

Injuries in youth football and the relationship to player maturation: An analysis of time-loss injuries during four seasons in an English elite male football academy.

A better insight into injuries in elite-youth football may inform prevention strategies. The purpose of this prospective cohort study was to investigate the frequency, incidence, and pattern of time-loss injuries in an elite male football academy, exploring injuries in relation to age and maturation status. Across four consecutive playing seasons, playing exposure and injuries to all academy players (U'9 to U'21) were recorded by club medical staff.

Is assuming additivity of single-metal toxicity thresholds a conservative approach to assessing risk of ecotoxicity from elevated soil concentrations of cobalt, copper, and nickel at contaminated sites?

Multiple metal-impacted soils are often realistic scenarios for risk assessments, but tools to address these are currently lacking. The objective of this work was to evaluate whether assuming concentration addition (CA) of metal mixture effects was conservative for prospective risk assessment of soils that were elevated mainly in Ni and Cu and somewhat with Co, Pb, or As. Observed whole mixture toxicity for field soils with aged metal mixtures was compared to the expected whole mixture toxicity, assuming additivity of prospective single-metal thresholds ("toxic units") for the mixture components.

Modeling phytoremediation of aged soil Ni from anthropogenic deposition using Alyssum murale.

Several field-scale phytoextraction scenarios were created in a greenhouse study to investigate the feasibility of using Alyssum murale, to remediate three types of industrially Ni-contaminated soil (heavy clay, sand, organic muck) from Port Colborne, Ontario. The observed distribution of Ni mass between soil and aboveground vegetation was used in STELLA modeling software to predict timelines for the target soil Ni concentration, namely 1200 mg Ni/kg. Alyssum murale grown in sand would have a relatively constant pool of Ni available for plant uptake, which would not be the case for plants grown in organic muck and heavy clay.

Introducing the Adverse Ecosystem Service Pathway as a Tool in Ecological Risk Assessment.

Soils provide numerous ecosystem services (ESs) such as food production and water purification. These ESs result from soil organism interactions and activities, which are supported by the soil physicochemical properties. Risk assessment for this complex system requires understanding the relationships among its components, both in the presence and absence of stressors.

Accuracy of Metabolic Cost Predictive Equations During Military Load Carriage.

Vine, CA, Coakley, SL, Blacker, SD, Doherty, J, Hale, B, Walker, EF, Rue, CA, Lee, BJ, Flood, TR, Knapik, JJ, Jackson, S, Greeves, JP, and Myers, SD. Accuracy of metabolic cost predictive equations during military load carriage. J Strength Cond Res 36(5): 1297-1303, 2022-To quantify the accuracy of 5 equations to predict the metabolic cost of load carriage under ecologically valid military speed and load combinations.

Risk Factors for Poststroke Shoulder Pain: A Systematic Review and Meta-Analysis.

Objective: To identify the risk factors identified within 1-month poststroke that predict the onset of poststroke shoulder pain (PSSP) within the first year after stroke.

Methods: Five databases (AMED, CINAHL, EMBASE, Medline, and PubMed) were searched from inception to April 2019. Prospective cohort studies that measured a potential risk factor for PSSP within the first month after stroke were included.

Metal oxides and annealed metals as alternatives to metal salts for fixed-ratio metal mixture ecotoxicity tests in soil.

In soil metal ecotoxicology research, dosing is usually performed with metal salts, followed by leaching to remove excess salinity. This process also removes some metals, affecting metal mixture ratios as different metals are removed by leaching at different rates. Consequently, alternative dosing methods must be considered for fixed ratio metal mixture research.

Single metal and metal mixture toxicity of five metals to Oppia nitens in five different Canadian soils.

Metal mixture toxicity across soil types is a daunting challenge to risk assessment. Here, we evaluated metal mixture toxicity in Oppia nitens, using ten fixed metal mixture ratios in five Canadian soils that closely matched some of the EU PNEC reference soils. Soils were dosed with five metals (Cu, Zn, Pb, Co, Ni) as single metals (ten concentrations) and as mixtures (eight concentrations).

Toxicity assessment of metal mixtures to soil enzymes is influenced by metal dosing method.

Metals are present as mixtures in the environment, yet testing such complex mixture poses design and technical challenges. One possible solution is the use of fixed ratios, i.e.

The forgotten role of toxicodynamics: How habitat quality alters the mite, Oppia nitens, susceptibility to zinc, independent of toxicokinetics.

Soil habitat quality is thought to influence metal toxicity via changes in speciation and thereby toxicokinetics. Here, we assessed the toxicokinetic and toxicodynamic effects of habitat quality on mite, Oppia nitens when exposed to zinc (Zn) contaminated soils. Forty-seven soils were ranked into three habitat qualities; high, medium, and low based on biological reproduction of Folsomia candida, Enchytraeus crypticus, and Elymus lanceolatus.

Bioaccessibility estimates by gastric SBRC method to determine relationships to bioavailability of nickel in ultramafic soils.

Frameworks for human health risk assessment often include the opportunity to correct the estimate of exposure for bioavailability, which could be predicted from bioaccessibility. Lead and As are the only metallic elements for which bioavailability and bioaccessibility have been correlated across a spectrum of mineralogy and particle types. The objective of the present study is to correlate in vivo bioavailability with ex vivo bioaccessibility for elevated Ni in soils of ultramafic origin and explore attribution of any variation in this correlation to mineralogical characterization of the Ni.

Multigenerational exposure of populations of Oppia nitens to zinc under pulse and continuous exposure scenarios.

Current soil remediation guidelines for metals reflect single-generation laboratory studies, but in the field, organisms are exposed to metals for more than one generation. The present study assessed the multigenerational effect of zinc (Zn) on Oppia nitens under a pulse or continuous exposure scenario. Synchronized adult mites (parents) were exposed to 6 concentrations of Zn in a field soil.

A potential new oral mapping (OM) method in the clinical evaluation and documentation of oral submucous fibrosis-A prospective clinical crossover study.

Background: Despite much research, there is a lack of a definite protocol or method for documenting oral submucous fibrosis (OSMF) site presentation. In this study, we propose a new potential oral mapping (OM) method and evaluated its use in recording OSMF-affected mucosal sites.

Methods: Fifty OSMF patients were evaluated by 15 primary care dental practitioners using both, a conventional subjective recording method and a new OM method, to document the degree of involvement of affected oral mucosa with a crossover study design.

Cognitive fatigue effects on physical performance: A systematic review and meta-analysis.

Recent research has examined the effect that undertaking a cognitively fatiguing task for ≤90 min has on subsequent physical performance. Cognitive fatigue is claimed to affect subsequent physical performance by inducing energy depletion in the brain, depletion of brain catecholamine neurotransmitters or changes in motivation. Observation of the psychophysiology and neurochemistry literature questions the ability of 90 min' cognitive activity to deplete energy or catecholamine resources.

TFM classification and staging of oral submucous fibrosis: A new proposal.

Background: We have evaluated the rationale of existing grading and staging schemes of oral submucous fibrosis (OSMF) based on how they are categorized. A novel classification and staging scheme is proposed.

Methods: A total of 300 OSMF patients were evaluated for agreement between functional, clinical, and histopathological staging.