Publications by authors named "Beverley Beynon-Cobb"
Article Synopsis
- * A study involving 1,453 participants from TwinsUK found a positive link between DAL and early-stage CKD, identifying various metabolites connected to both.
- * Certain metabolites, particularly from stool samples, showed a relationship with gut microbial species, highlighting the potential for gut microbiota interventions to mitigate the effects of DAL on CKD progression; however, further research is needed to confirm causality.
Maintaining an appropriate acid-base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and magnesium, and the organic acids from foods, which are metabolized to bicarbonate and thus have an alkalinizing effect.
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- * A systematic review of 14 randomized trials (over 2000 participants) indicated that sodium bicarbonate therapy did not significantly change systolic BP, nor did it increase the use of antihypertensive medications among CKD patients.
- * The study concluded that sodium bicarbonate may not adversely impact blood pressure, highlighting the need for further investigation into its long-term effects in CKD management.