Publications by authors named "Bevan Johnson"
Article Synopsis
- The study investigates how the loss of Pim kinases contributes to cardiac aging by impairing mitochondrial function and energy production.
- It finds that genetic deletion of Pim kinases in mice leads to early signs of heart failure, metabolic dysfunction, and cellular changes associated with aging.
- The research concludes that Pim kinases play a crucial role in protecting heart health and maintaining mitochondrial integrity, offering insights that could help counteract cardiac aging.
Mitochondrial morphological dynamics affect the outcome of ischemic heart damage and pathogenesis. Recently, mitochondrial fission protein dynamin-related protein 1 (Drp1) has been identified as a mediator of mitochondrial morphological changes and cell death during cardiac ischemic injury. In this study, we report a unique relationship between Pim-1 activity and Drp1 regulation of mitochondrial morphology in cardiomyocytes challenged by ischemic stress.
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