Publications by authors named "Betul Seyhan"
Article Synopsis
- The study used qRT-PCR to assess the expression of a specific gene and various miRNAs in thyroid tumors and nearby noncancerous tissues, as well as to check the methylation status of the gene's promoter.
- There was a significant decrease in the gene's expression in tumors compared to noncancerous tissues, while the levels of miR-182, miR-183, and miR-375 were higher in the tumors.
- The findings suggest that the gene plays a role in the development of papillary thyroid carcinoma and that its regulation is influenced more by miRNAs than by promoter methylation.
: Wnt signaling pathway is associated with a variety of human cancers, including HNSCC. Wnt proteins control cellular events such as proliferation, fate specification, polarity, and migration by transducing signals to the nucleus through several cytoplasmic relay proteins. Although activation of the Wnt/β-catenin pathway is a frequent event in various cancers, there is limited knowledge on the contribution of this signaling mechanism in HNSCC.
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- CT120 is a protein with seven transmembrane domains involved in cell growth and survival, showing a significant role in lung cancer development and signaling pathway activation.
- c-Myc, a key transcription factor in cancer, regulates gene expression and is often amplified in various cancers, including head and neck squamous cell carcinoma (HNSCC).
- The study found that c-Myc binds to E-boxes in the promoter region and that CT120 is hypomethylated and overexpressed in 56% of HNSCC samples, indicating its contribution to cancer progression coupled with c-Myc's higher expression in tumor tissues.