Non-invasive electrochemical immunosensor for reverse iontophoretic determination of cardiac troponins (cTnT & cTnI) in a simulated artificial skin model. Significance of raw DPV and CV data for chemometric discrimination.

Electrochemical immunosensors coupled with reverse iontophoresis (RI) for noninvasive determination of cardiac troponins were developed and validated according to ICH Q2 (R1) guideline. Linearity was in 0.01-10 and 100-500 ng/mL ranges.