[Determination of estradiol receptors in the endometrium--a contribution to the diagnosis of functional sterility].

In 86 cases of female infertility an endometrial biopsy was performed. The received tissues were examined by histological methods and the binding of estradiol on the specific cytoplasmic receptor was studied. Serum levels of estradiol and progesterone were estimated at the same day.

[Endometriosis within the scope of sterility treatment].

Endometriosis is one of the most frequent diseases in connection with female sterility, 3.2 per cent endometriosis was diagnosed in all operative cases from 1964 to 1984 but in all cases of sterility there were 10.8 per cent.

[Detection of estradiol receptors in the cyclic endometrium].

In 41 women the 17 beta-estradiol-receptors were determined in the cytosol fraction. The highest concentrations were found in cases of glandular-cystic hyperplasia, were as in the cyclic endometrium the highest concentrations were recognized before the date of ovulation at a rate of 189,8 +/- 80 fmol/mg protein. --During the treatment with contraceptive drugs only a small content of receptors was observed in midcycle.

[Melanoma of the female urethra].

Case report of a 69-year-old woman with a melanoma of the urethra. Radical surgery was renounced in regard of the age. We performed local excision with inguinal lymphonodectomy only followed by chemotherapy with dacarbazine.

[Acute abdomen caused by an intrauterine device].

Case report about late complications caused by lying intrauterine devices (IUD). Ileus by strangulation represents a rare event when a closed IUD has perforated partially. A pelvic roentgenographic examination alone is not sufficient in order to give an estimation of the present position of the IUD.

[Significance of prostaglandin formation in the endometrium for cycle regulation in the female].

By taking 91 samples of tissue the contents of PGE2 and PGF2 alpha in the cyclic endometrium was detected. Until the beginning of the menstruation a continuous rise of both substances could be observed. Especially during the latter half of the cycle the concentration of PGF2 alpha increased fundamentally causing a shifting within the relationship of both primary prostaglandins in favour of PGF2 alpha at the end of the cycle.

[Detection of prostaglandins from decidua (author's transl)].

PGE2 and PGF2 alpha were isolated from the decidua of an early pregnancy, following medical termination. The biosynthetic capacity for 6-keto-F1 alpha was tested by incubation, using 3H-labelled arachidonic acid. Prostaglandin concentrations in the decidua differed strongly from steroid hormones in plasma.

[Radio-immunological testing of progesterone for diagnosis of corpus luteum insufficiency (author's transl)].

Radio-immunological assay was used to determine progesterone concentrations in serum during the luteal phase in 34 patients with treated and untreated corpus luteum insufficiency. Twenty patients with normal menstruation cycles were used as controls. Progesterone levels were found to be in agreement with the histological pattern of the endometrium.

[Case history of clinical course of Buschke-Loewenstein tumour (author's transl)].

Described in this paper is the case of a woman, 59 years of age, in whom an extended giant condyloma of the vulva was removed, with the patient cured, by several surgical interventions. The problems relating to such benign tumours are discussed.

[The microprobe excision as a search biopsy within the scope of cancer-trace detection on the cervix uteri].

Besides colposcopy and cytology microbiopsy as a detection method for early detection of malign cervical lesions was applied to 142 women patients of the UFK Halle. A precondition for the successfull application of this method is a carefull preliminary colposcopic examination and close co-operation with the histologist. The interim result of the microbiopsy corresponded to a high degree with the definitive result.

[Corpus luteum function in the middle luteal phase following treatment with prostaglandins].

The corpus luteum of the mid-luteal phase was examined concerning of the signs of functional and morphological regression after treatment with Prostin F2alpha and 15(S)-15-methyl-PGF2alpha. By 8 patients who were operated upon out of various uterine indications steroid hormone levels were determined during the treatment with prostaglandins and corpus luteum was judged by electron-microscopy. Morphological changes in the temporary decrease of the progesteron concentration could be found.

[The question of the innervation of the umbilical cord].

By supravital Methylenbluestaining a dense network of vegetative nerve fibres is demonstrated in the adventitia arround the arteries of the umbilical cord. Some of these nerve fibres are of cholinergic nature.