The BCG vaccine can cause serious local reactions or infections in immunocompromised individuals, as illustrated by a six-month-old boy who developed lesions and respiratory issues after vaccination.
A diagnosis identified the presence of Mycobacterium bovis BCG and revealed the child had severe combined immunodeficiency due to a mutation in the IL2RG gene.
The case emphasizes the importance of prompt diagnosis and appropriate treatment, highlighting the potential risks for vulnerable populations following vaccination.