Publications by authors named "Betty M Chung"
Article Synopsis
- The 8th edition of the AJCC TNM staging system categorizes advanced prostate cancer (pT3 tumors) into three groups: pT3a (extraprostatic extension), pT3b (seminal vesicle invasion), and a proposed pT3c (both EPE and SVI).
- A study of 69 prostate cancer patients showed that those with both SVI and EPE had a significantly higher biochemical recurrence rate (33.9%) compared to those with SVI alone (12.5%).
- An additional cohort of 88 patients revealed that lymph node metastasis was also more prevalent in the combined SVI and EPE group (29%) versus the SVI only group (10%),
Integrin-mediated adhesion to substratum is required for cyclin D1 induction in mesenchymal cells, but we show here that the induction of cyclin D1 persists despite blockade of ECM-integrin signaling in MCF10A mammary epithelial cells. E-cadherin-mediated cell-cell adhesion also supports cyclin D1 induction in these cells, and the combined inhibition of both E-cadherin and integrin adhesion is required to prevent the expression of cyclin D1 mRNA and protein. Our previous studies described a pro-proliferative effect of E-cadherin in MCF10A cells, mediated by Rac, and we now show that Rac is required for cyclin D1 mRNA induction by both E-cadherin and integrin engagement.
View Article and Find Full Text PDFp21(cip1) inhibits S phase entry by binding to cyclin-cdk2 (cyclin-dependent kinase-2) complexes. The levels of p21(cip1) are rapidly induced after mitogenic stimulation of quiescent fibroblasts and then down-regulate as the cells reach late G(1) phase and activate cyclin E-cdk2. In this study, we have shown that pharmacological inhibition of protein kinase C (PKC), expression of dominant negative PKCdelta, or knockdown of PKCdelta with small interfering RNA elevates p21(cip1) protein levels in mouse embryo fibroblasts.
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