Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia.

Preterm infants are susceptible to neonatal inflammatory/infective diseases requiring drug therapy. The present study hypothesized that mRNA expression in the blood may be modulated by signaling pathways during treatment. The current study aimed to explore changes in global gene expression in the blood from preterm infants with the objective of identifying patterns or pathways of potential relevance to drug therapy.

Probable topiramate-induced diarrhea in a 2-month-old breast-fed child - A case report.

An infant developed a severe condition of recurrent and persistent watery diarrhea at 40 days of age. The child had been partially breast-fed, and the mother used topiramate for epilepsy. Hospital examination excluded a viral or bacterial infection and failed to identify any other potential cause.

Compatibility of drug infusions in the NICU.

Objectives: The majority of drugs used in sick newborns receiving intensive care are unlicensed and off-label, exposing infants to greater risk of adverse drug reactions (ADRs). Our aim was to study the compatibility of co-infusions for a selected group of drugs and nutrition solutions as part of our quality assurance programme in the neonatal intensive care unit.

Methods: The authors reviewed drug studies in the literature.

Dosage and formulation issues: oral vitamin E therapy in children.

Purpose: Oral vitamin E is used in several childhood diseases, but dosage recommendations differ. Few oral products have a marketing authorization for therapeutic use in children. Preliminary data indicate differences in bioavailability among the various vitamin E compounds.

[Vitamin E mixture for children--treatment with a blindfold?].

Background: Vitamin E is used in children with different diagnoses and conditions, including premature babies and infants. In Norway, there is no licensed vitamin E formulation designed for children. Consequently, extemporaneous production is carried out in pharmacies.