Publications by authors named "Betty Couderc"
Article Synopsis
- Preeclampsia (PE) is a pregnancy-related condition defined by issues like high blood pressure, protein in urine, and problems with the placenta, and is modeled in mice by the overexpression of the STOX1A transcription factor.
- Research shows that STOX1A overexpression disrupts nitric oxide production and mitochondrial function in trophoblasts, which leads to a disturbance in the Krebs cycle and lower levels of a key metabolite, l-malate.
- Administering tetrahydrobiopterin (BH4) restores these disrupted processes in vitro and in rodent models, suggesting BH4 could be a promising treatment for alleviating symptoms of preeclampsia, such as placental
STOX1 is a transcription factor involved in preeclampsia and Alzheimer disease. We show that the knock-down of the gene induces rather mild effect on gene expression in trophoblast cell lines (BeWo). We identified binding sites of STOX1 shared by the two major isoforms, STOX1A and STOX1B.
View Article and Find Full Text PDFPreeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The objective of the present study is to evaluate the cardiovascular dysfunction induced by preeclampsia by examining the endothelium of mice suffering of severe preeclampsia induced by STOX1 overexpression.
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