Investigating the Role of Salivary Cortisol on Vocal Symptoms.

Purpose: We investigated whether participants who reported more often occurring vocal symptoms showed higher salivary cortisol levels and if such possible associations were different for men and women.

Method: The participants (N = 170; men n = 49, women n = 121) consisted of a population-based sample of Finnish twins born between 1961 and 1989. The participants submitted saliva samples for hormone analysis and completed a web questionnaire including questions regarding the occurrence of 6 vocal symptoms during the past 12 months.

Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene.

Purpose: Oxytocin and arginine vasopressin are associated with different aspects of the stress response. As stress is regarded as a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single-nucleotide polymorphisms (SNPs) and vocal symptoms. We also wanted to explore whether such effects might be mediated by cortisol because oxytocin and vasopressin are associated with cortisol levels.

Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking.

The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consume alcohol in rodents. Moreover, ghrelin signaling is required for the rewarding properties of addictive drugs including alcohol and nicotine in rodents.

[Development of substance use disorders can be prevented].

The first experiments with intoxicants take place in early adolescence, and the drug use habits become established during adolescence. In addition to an early start of substance abuse and adolescent drug problems, especially ADHD and behavior disorders predispose to subsequent substance use disorders. Prevention and effective treatment of these disturbances can decrease the risk of subsequent development of substance use disorders.

The Genetics of Sexuality and Aggression (GSA) twin samples in Finland.

The Genetics of Sexuality and Aggression (GSA) project was launched at the Abo Akademi University in Turku, Finland in 2005 and has so far undertaken two major population-based data collections involving twins and siblings of twins. To date, it consists of about 14,000 individuals (including 1,147 informative monozygotic twin pairs, 1,042 informative same-sex dizygotic twin pairs, 741 informative opposite-sex dizygotic twin pairs). Participants have been recruited through the Central Population Registry of Finland and were 18-49 years of age at the time of the data collections.

Changes in the prevalence of child sexual abuse, its risk factors, and their associations as a function of age cohort in a Finnish population sample.

Objective: We examined (1) the prevalence of childhood sexual abuse (CSA) experiences as a function of cohort and gender, (2) the prevalence of factors associated with CSA as a function of cohort and whether the association of these factors with CSA remained the same irrespective of cohort, and (3) whether any cohort differences could be explainable by cohort differences in reporting bias.

Method: We used the responses of 4,561 men (M=29, SD=7 years) and 8,361 female (M=29, SD=7 years) Finnish participants who responded to the Childhood Trauma Questionnaire-Short Form as well as questions regarding family structure.

Results: The prevalence of CSA experiences varied between 0.

Controlling anger in self-reported sober and alcohol intoxicated states: moderating effects of trait anger and alcohol consumption.

Controlling anger in self-reported sober and alcohol intoxicated states: Moderating effects of trait anger and alcohol consumption. Scandinavian Journal of Psychology 52, 382-388. Retrospective self-reports about prior sober and alcohol intoxicated states were explored to reveal moderating effects of trait anger and alcohol consumption on anger control.

Genetic effects on anger control and their interaction with alcohol intoxication: a self-report study.

Individual differences in anger control are important to consider when trying to understand intoxicated aggression (Parrott and Giancola, 2004). We explored, first, genetic and environmental effects on anger control both in self-reported sober and alcohol intoxicated states, and whether the same genetic and environmental effects influence it in both these states, and second, a possible interaction between genetic effects and alcohol in the control of anger. In the population based sample (N=8964) of Finnish twins (18-33 years) and their siblings (18 years or older), genetic effects on anger control were found both for the self-reported sober (27% for men, 34% for women) and alcohol intoxicated states (29% for men, 37% for women), with high genetic correlations (from .

Childhood sexual interactions with other children are associated with lower preferred age of sexual partners including sexual interest in children in adulthood.

Associations between childhood sexual interactions with other children, and preferred and actual age of sexual partners, as well as adults' sexual interest in children, were explored in a sample of 1312 Finnish male twins. Experience of sexual interaction with other children was associated with lower minimum age of preferred and actual sexual partners in adulthood. In addition, such interactions were connected to an increased likelihood of adults' sexual interest in children under the age of 16 years.

Subjectively measured ejaculation latency time and its association with different sexual activities while controlling for age and relationship length.

Introduction: Recently, attempts to formulate valid and suitable definitions for (different subcategories of) premature ejaculation have resulted in substantial progress in the pursuit to gain knowledge about ejaculatory function. However, the association between ejaculatory dysfunction and different types of sexual activities has yet to be thoroughly investigated, and (due to conflicting results between studies) the potential effects of age and relationship length still need to be taken into account.

Aim: The aim of this study is to investigate the associations of age, relationship length, frequency of different sexual activities, and different modes of achieving ejaculation with self-reported ejaculation latency time.

Psychiatric symptoms and same-sex sexual attraction and behavior in light of childhood gender atypical behavior and parental relationships.

This study explores the relation between the level of current symptoms of depression and anxiety and recalled childhood gender atypical behavior (GAB), and quality of relationships with parents among men and women who reported same-sex sexual attraction or engaged in same-sex sexual behavior and men and women who did not. Matched pairs, 79 men (n = 158) and 148 women (n = 296), with equal levels of GAB were created of Finnish participants with either same-sex sexual attraction or behavior and participants without. The measures used were retrospective questionnaires.

Common genetic effects of gender atypical behavior in childhood and sexual orientation in adulthood: a study of Finnish twins.

The existence of genetic effects on gender atypical behavior in childhood and sexual orientation in adulthood and the overlap between these effects were studied in a population-based sample of 3,261 Finnish twins aged 33-43 years. The participants completed items on recalled childhood behavior and on same-sex sexual interest and behavior, which were combined into a childhood gender atypical behavior and a sexual orientation variable, respectively. The phenotypic association between the two variables was stronger for men than for women.

Significance of family life events in middle adolescence: a survey on Finnish community adolescents.

Finnish middle adolescents (n=3242) were assessed for family characters, family life events, depression and frequent drunkenness. Odds ratios for maladjustment outcomes associated with each event were computed and logistic regression models were used to estimate the effect of confounders. In the presence of serious illness or injury of a family member, increasing conflicts between parents and financial difficulties in the family, the probability of depression was twice as high than without the presence of these events.

Female sexual dysfunction, sexual distress, and compatibility with partner.

Introduction: Few studies have looked at prevalence estimates for female sexual dysfunctions in combination with personal distress, although existing diagnostic criteria for sexual disorders include both aspects. Further, the variation in female sexual function has been shown to be largely explained by unique nongenetic factors. Such factors may include partner sexual function and perception of sexual compatibility with a partner, factors which may also be associated with sexual distress.

Retrospective reports of parental physical affection and parenting style: a study of Finnish twins.

Individual differences in parenting behaviors are due, in part, to genetic factors. In the present study, the authors sought to determine whether the degree of genetic influence varied according to the type of parental behavior under consideration. A population-based sample of 2,334 pairs of Finnish twins provided ratings on the physical affection, control, abusiveness, and indifference shown by their father and mother during childhood.

Factor structure of the Alcohol Use Disorders Identification Test (AUDIT) for men and women in different age groups.

Objective: Our main aim was to investigate the factor structure of the Alcohol Use Disorders Identification Test (AUDIT) in a Finnish population sample.

Method: The AUDIT was completed by 3,125 men (mean age = 26.2 years) and 6,006 women (mean age = 26.

Indicators of premature ejaculation and their associations with sexual distress in a population-based sample of young twins and their siblings.

Introduction: Recently, in anticipation of the Diagnostic and Statistical Manual of Mental Disorders V, much consideration has been given to the diagnostic criteria for premature ejaculation (PE). The scientific community is yet to agree not only on the etiology of PE, but also on the most suitable diagnosis and forms of treatment. It has been suggested that the diagnostic criteria of PE should be strictly empirical and rely on intravaginal latency time alone, whereas others stress the need to also include psychological and personal factors.

Do the same genetic and environmental effects underlie the covariation of alcohol dependence, smoking, and aggressive behaviour?

We investigated genetic and environmental effects on alcohol dependence, smoking, and aggressive behaviour, as well as sex differences in these effects and whether these effects were the same for the three phenotypes. There were 3141 male (mean age 26.2 [S.

Potential for homosexual response is prevalent and genetic.

We investigated the potential to engage in homosexual behavior in 6001 female and 3152 male twins and their siblings finding that 32.8% of the men and 65.4% of the women reported such potential (p<0.

Premature and delayed ejaculation: genetic and environmental effects in a population-based sample of Finnish twins.

Introduction: A number of different theoretical approaches to understanding the etiology of ejaculatory dysfunction have been proposed, but no behavior genetic study has yet, to our knowledge, been conducted to explore the genetic and environmental influences on ejaculatory dysfunction.

Aim: The aim of the present study was to explore the genetic and environmental effects on premature (PE) and delayed (DE) ejaculation in a population-based sample.

Methods: The genetic and environmental influences on PE and DE were investigated in a population-based sample of 1,196 Finnish male twins, age 33-43 years, with 91 identical and 110 complete twin pairs.

Adult and peer involvement in help-seeking for depression in adolescent population: a two-year follow-up in Finland.

Help-seeking among adolescents and adults is often perceived as a process involving only the health care system and the individual suffering from psychiatric symptoms. The present study attempted to create a model of help-seeking also including members of adolescents social networks. A prospective follow-up design included a school-based survey on all ninth grade students (mean age 15.

Genetic effects on male sexual coercion.

The genetic and environmental influences on sexual coercion, and to what extent its associations with alcohol use and psychopathy depend on shared genetic and environmental effects, were explored in a Finnish population-based sample of 938 men, aged 33-43 years, using the classical twin study design. All three phenotypes were associated positively and affected by genes (sexual coercion 28%, alcohol use 60%, psychopathy 54%), with 46% of the correlation between sexual coercion and psychopathy, 89% of the correlation between alcohol use and psychopathy and 100% of the correlation between sexual coercion and alcohol use being explained by shared genetic effects. Further, the results showed that a proportion of the variance in sexual coercion was derived from a highly genetic source that was common with alcohol use and psychopathy.

Continuity, comorbidity and longitudinal associations between depression and antisocial behaviour in middle adolescence: a 2-year prospective follow-up study.

The study investigated continuity, comorbidity and longitudinal associations between depression Beck depression inventory (RBDI) and antisocial behaviour Youth self-report (YSR) in middle adolescence. Data were used from a community sample of 2070 adolescents who participated in a 2-year prospective follow-up study. The results indicate that both depression and antisocial behaviour had considerable continuity, and concurrent comorbidity between these disorders was strong.

Perceived financial difficulties and maladjustment outcomes in adolescence.

Background: Studies using traditional SES indicators in strictly adolescent populations have usually failed to find class differences in adolescent mental health. The present study aimed to find out whether there is an association between adolescent perceived financial difficulties of the family and adolescent maladjustment, and to explore the possible sex differences in this association.

Methods: School-based survey on 3278 ninth grade students (15-16 years old) in two economically well developed Finnish cities.