Publications by authors named "Bettina Remmel"
Mol Cell Biol
February 2003
Article Synopsis
- Nuclear receptors are transcription factors that respond to ligands, with FXRbeta identified as a novel member of this family, functional in certain animals but a pseudogene in humans.
- FXRbeta is coexpressed with FXR in various embryonic and adult tissues, working with RXRalpha to stimulate transcription when 9-cis-retinoic acid is present.
- The discovery of lanosterol as an endogenous ligand for mFXRbeta suggests its role in regulating cholesterol biosynthesis in nonprimate species, highlighting differences in cholesterol metabolism and influencing genetic and drug research.
