Publications by authors named "Betsy R Maller Schulman"
In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells.
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- Heterochronic genes in C. elegans, such as let-7 and lin-4, play a role in determining the timing of cell fate by down-regulating lin-41 through their microRNA functions.
- Researchers have cloned and sequenced the lin-41 orthologs in mammals, finding conserved sites for let-7 and mir-125 in their 3'UTRs.
- Mouse lin-41 is expressed during embryonic development, particularly in limb buds, and is down-regulated when let-7c and mir-125 levels increase, indicating its role in controlling limb formation.