Antiplatelet effects and pharmacodynamics of clopidogrel in cats.

Objective: To evaluate antiplatelet effects and pharmacodynamics of clopidogrel in cats.

Design: Original study.

Animals: 5 purpose-bred domestic cats.

Evaluation of antiplatelet effects of ticlopidine in cats.

Objective: To determine whether ticlopidine exerts an antiplatelet effect, estimate the pharmacodynamics of ticlopidine, and evaluate any acute adverse effects associated with administration of ticlopidine in cats.

Animals: 8 domestic purpose-bred sexually intact male cats.

Procedure: Ticlopidine was administered orally (50 mg, q 24 h; 100 mg, q 24 h; 200 mg, q 24 h; and 250 mg, q 12 h).