Publications by authors named "Betiana Perez"
The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood; and antiresorptive agents, the current standard of care, do not restore the weakened bone architecture. Herein, we reveal the diabetic bone signature in mice at the tissue, cell, and transcriptome levels and demonstrate that three FDA-approved bone-anabolic agents correct it. Diabetes decreased bone mineral density (BMD) and bone formation, damaged microarchitecture, increased porosity of cortical bone, and compromised bone strength.
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- The study aimed to create a framework for healthcare professionals to effectively prevent and treat glucocorticoid-induced osteoporosis (GIO) in postmenopausal women and men aged 50 or older who are undergoing glucocorticoid therapy.
- The expert panel employed a structured approach (PICO) and used GRADE methodology for a systematic literature review, producing 17 recommendations and 8 general principles for evaluating and treating patients at risk of GIO.
- The guidelines emphasize the importance of monitoring bone health, managing lifestyle factors, and preventing fragility fractures, with the ultimate goal of maintaining or improving bone mineral density in affected patients.*
Context: Hypoparathyroidism is a rare disease and, as such, its natural history, long-term complications, and correct clinical management remain unclear.
Objective: To describe the natural history and clinical characteristics of the disease.
Design And Setting: To present a retrospective observational analysis from 7 specialized centers in Buenos Aires, Argentina.