Publications by Bethany Coleman

Publications by authors named "Bethany Coleman"

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NRAS mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.

Patricia Pastura C Griffin McDaniel Sara Alharbi Dermot Fox Bethany Coleman

Pediatr Blood Cancer

July 2024

Background: Angiopoietin-2 (Ang-2) is increased in the blood of patients with kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE). While the genetic causes of KHE are not clear, a somatic activating NRAS mutation has been found in the lesions of KLA patients.

Procedure: Our study tested the hypothesis that the NRAS mutation drives elevated Ang-2 expression in endothelial cells.

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