Publications by authors named "Bethany A Masson"
Article Synopsis
- The paternal environment before conception can affect the physiology and behavior of offspring, with changes in the sperm epigenome playing a key role in non-genetic inheritance.
- A study on male mice showed that depleting their gut microbiome with antibiotics led to their offspring having lower body weight, altered gut morphology, and significant changes in emotional behaviors like anxiety and depression.
- The research identified that gut microbiome depletion affected the expression of specific small RNAs in sperm, suggesting that paternal gut health influences epigenetic inheritance and could have implications for other species, including humans.
Huntington's disease (HD) is a neurodegenerative disorder involving psychiatric, cognitive and motor deficits, as well as peripheral symptoms, including gastrointestinal dysfunction. The R6/1 HD mouse model expresses a mutant human huntingtin transgene and has been shown to provide an accurate disease model. Recent evidence of gut microbiome disruption was shown in preclinical and clinical HD.
View Article and Find Full Text PDFHuntington's disease (HD) is a fatal neurodegenerative disorder caused by an autosomal dominant trinucleotide (CAG) tandem repeat, resulting in complex motor, psychiatric and cognitive symptoms as well as gastrointestinal disturbances and other peripheral symptoms. There are currently no disease-modifying treatments, and the peripheral pathology of the disorder is not well understood. Emerging evidence suggests that the bi-directional communication pathways between the gut and the brain, including the microbiota-gut-brain axis, can affect motor, psychiatric and cognitive symptoms as well as weight loss and sexual dimorphism seen in HD.
View Article and Find Full Text PDFArticle Synopsis
- - Huntington's disease is a serious neurodegenerative disorder that affects the brain and body, and currently has no effective treatments to slow its progression.
- - Recent research indicates that disruptions in the gut microbiome may influence cognitive function in Huntington's disease, which suggests a link between gut health and brain health known as the microbiota-gut-brain axis.
- - A study found that fecal microbiota transplant (FMT) from healthy mice improved cognitive abilities in female Huntington's disease mice; however, male mice showed less success due to more significant gut microbiome changes and imbalances, indicating a potential new therapeutic approach.