Publications by authors named "Beth Morrel"

Background: Vulvar lichen sclerosus (VLS) is a chronic remitting condition that affects the genital skin of females of all ages. Although qualitative studies have been conducted that have focused on women with VLS in mid-life or beyond, less is known about the experiences of individuals with VLS from childhood or adolescence onward.

Objectives: To gain an understanding of the experiences of women with a history of juvenile VLS (JVLS) with regard to the impact of the disease on their personal lives, and their experiences and needs regarding care and guidance.

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Article Synopsis
  • A Delphi study has established core outcome domains (CODs) for treating adult vulvar lichen sclerosus (VLS), focusing on physical findings and quality of life (QoL).
  • A systematic search identified 26 standardized measurement tools across six outcome areas, including general health, VLS-specific QoL, symptoms, clinical signs, emotional impact, and sexual functioning.
  • The research highlights inconsistencies in using these measurement tools, indicating a need for a comprehensive study to create a consensus regarding evaluation methods that consider predetermined CODs and factors like age.
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Objectives: Studies on the consequences of juvenile vulvar lichen sclerosus (JVLS) in adulthood are limited. A number of measuring tools are available for analyzing adult vulvar lichen sclerosus (VLS), but these have not been applied in studies on JVLS. The aim is to study physical findings, quality of life, sexual well-being, and self-image in adult women with a history of juvenile VLS.

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Introduction: Vulvar lichen sclerosus (VLS) occurs in at least one in 900 girls. There is limited knowledge as to what extent the disease persists in adulthood and what the repercussions in adulthood may be. The aim of this study is to evaluate the long-term consequences of VLS diagnosed in childhood or adolescence.

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Cases of vulvar melanocytic lesions in juveniles are rarely reported. We analyze the evidence regarding vulvar melanocytic lesions in juveniles with or without vulvar lichen sclerosus to help decision making by clinicians and pathologists. A scoping review on vulvar melanocytic lesions with or without vulvar lichen sclerosus, including malignant vulvar melanomas, in females up to age 18 years was performed.

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Article Synopsis
  • A systematic review was conducted to compare how lichen sclerosus affects boys and girls, focusing on epidemiology, symptoms, genetics, risk factors, treatment, and prognosis.
  • Out of 1780 articles reviewed, 90 met the criteria, revealing that boys and girls exhibit similar clinical characteristics but have different treatment and follow-up approaches.
  • The findings suggest the need for further research, particularly on follow-up care, to enhance understanding and management of lichen sclerosus in children.
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Seborrheic keratoses (SKs) are benign lesions of uncertain etiology, which can develop in both genital and extra-genital locations. For genital SKs, there has been conjecture about the pathogenic role of human papillomavirus (HPV), in view of the frequent association of this virus with genital lesions. In light of the potential consequences on patient management, we investigated the relationship between HPV and SKs of the female genital tract (FGT).

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Genital lichen sclerosus (LS), a chronic noninfectious dermatosis, is not rare in pediatric dermatology. The histopathological diagnosis in children and adults in both genital and nongenital LS is considered to be the same and encompasses a broad range of possible characteristics. Clinical manifestations and treatment options of genital LS in children are different depending on gender.

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Background: Vulvar lichen sclerosus (VLS) occurring in children and adolescents may have repercussions throughout life.

Objective: We sought to assess the evidence available on the long-term consequences of juvenile VLS.

Methods: Multiple databases were searched for studies containing long-term follow-up information on children or adolescents up to age 18 years with VLS.

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