Publications by authors named "Beth M Elledge"
Biochemistry
October 2011
Article Synopsis
- Mitochondrial-nuclear communication is essential for retinal and retinal pigment epithelial (RPE) cells to adapt and survive under oxidative stress due to their high oxygen needs.
- A study found that the protein prohibitin plays a significant role in this communication, being upregulated in the retina but downregulated in RPE cells during aging and diabetes.
- Prohibitin acts as an anti-apoptotic molecule in mitochondria and facilitates communication with the nucleus, crucial for maintaining mitochondrial integrity under oxidative stress.
