Publications by authors named "Beth Elledge"
Int J Sci Eng Res
July 2017
Article Synopsis
- The retinal pigment epithelium (RPE) is crucial for eye health by protecting photoreceptors and removing waste during light exposure.
- Melatonin enhances the expression of key proteins like prohibitin and β-tubulin, affecting the RPE's cytoskeletal structure and aiding in oxidative stress protection.
- The study suggests melatonin could be a promising treatment for ocular diseases such as age-related macular degeneration by promoting healthier RPE cell morphology and function.
Biochemistry
October 2011
Article Synopsis
- Mitochondrial-nuclear communication is essential for retinal and retinal pigment epithelial (RPE) cells to adapt and survive under oxidative stress due to their high oxygen needs.
- A study found that the protein prohibitin plays a significant role in this communication, being upregulated in the retina but downregulated in RPE cells during aging and diabetes.
- Prohibitin acts as an anti-apoptotic molecule in mitochondria and facilitates communication with the nucleus, crucial for maintaining mitochondrial integrity under oxidative stress.
