Publications by authors named "Beth A Aperavich"
Article Synopsis
- Breast cancer risk is influenced by multiple genes, and researchers have identified a specific locus (Mcs5a) in rats that can reduce the risk of developing mammary cancer by 50% when certain alleles are present.
- The study pinpointed two non-coding elements (Mcs5a1 and Mcs5a2) that interact and affect cancer resistance, with one element influencing a gene involved in protein degradation (Fbxo10) and the other linked to another gene (Frmpd1).
- In human studies involving around 12,000 women, specific genetic variations (minor alleles) were found to be associated with breast cancer risk: one increased risk while the other decreased it, indicating the complex genetic basis of breast
To identify high-frequency, low-penetrance breast cancer modifier genes, we have developed a rat genetic model that uses the Wistar-Kyoto (WKy) inbred strain, resistant to developing 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis, as a congenic donor and the susceptible Wistar-Furth (WF) strain as the recipient. Here, data from congenic rat lines containing smaller WKy genomic intervals of the Mcs5 quantitative trait locus region are presented to fine map three independently acting Mcs5 subloci. WKy-homozygous females from congenic lines defining Mcs5a, Mcs5b, and Mcs5c averaged, respectively, 4.
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