First clinical implementation of a highly efficient daily online adapted proton therapy (DAPT) workflow.

This study presents the first clinical implementation of an efficient online daily adaptive proton therapy workflow (DAPT).The DAPT workflow includes awhere aand aare optimized on the planning computed tomography (CT). In the, theis re-optimized on daily images from an in-room CT.

Development and clinical validation of real-time artificial intelligence diagnostic companion for fetal ultrasound examination.

Objective: Prenatal diagnosis of a rare disease on ultrasound relies on a physician's ability to remember an intractable amount of knowledge. We developed a real-time decision support system (DSS) that suggests, at each step of the examination, the next phenotypic feature to assess, optimizing the diagnostic pathway to the smallest number of possible diagnoses. The objective of this study was to evaluate the performance of this real-time DSS using clinical data.

"Re-Materialized" Medical Data: Paper-Based Transmission of Structured Medical Data Using QR-Code, for Medical Imaging Reports.

Although paper-based transmission of medical information might seem outdated, it has proven efficient, and remains structurally safe from massive data leaks. As part of the ICIPEMIR project for improving medical imaging report, we explored the idea of structured data storage within a medical report, by embedding the data themselves in a QR-Code (and no URL-to-the-data). Three different datasets from ICIPEMIR were serialized, then encoded in a QR-Code.

Assessing abdominal aortic calcifications before performing colocolic or colorectal anastomoses: A case-control study.

Background: Preoperative evaluation needs objective measurement of the risk of anastomotic leakage (AL). This study aimed to determine if cardiovascular disease, evaluated by abdominal aortic calcification (AAC), was associated with AL after colorectal anastomoses. We conducted a retrospective case-control study on patients who underwent colorectal anastomosis between 2012 and 2016 at Reims University Hospital (France).

ICIPEMIR: Improving the Completeness, Interoperability and Patient Explanations of Medical Imaging Reports.

Introduction: Although electronic health records have been facilitating the management of medical information, there is still room for improvement in daily production of medical report. Possible areas for improvement would be: to improve reports quality (by increasing exhaustivity), to improve patients' understanding (by mean of a graphical display), to save physicians' time (by helping reports writing), and to improve sharing and storage (by enhancing interoperability). We set up the ICIPEMIR project (Improving the completeness, interoperability and patients explanation of medical imaging reports) as an academic solution to optimize medical imaging reports production.

Spatial analysis of hypospadias cases in northern France: taking clinical data into account.

Background: Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the epidemiology and pathophysiology of these anomalies. We aimed to evaluate spatial variations in hypospadias within our region and it's association to socioeconomic and ecological factors, taking clinical data into account.

Lactobionamide-based fluorinated detergent for functional and structural stabilization of membrane proteins.

Membrane proteins (MPs) are important drug discovery targets for a wide range of diseases. Conventional detergents such as n-Dodecyl β-D-maltoside have been used largely and efficiently to solubilize MPs with varying degrees of success concerning MPs functionality and stability. Fluorinated surfactants (FSs) have shown a great potential for the stabilization of various MPs.

Mental health status of individuals with sexual development disorders: A review.

Healthcare recommendations for people with disorders of sexual development (DSDs) include mental health attention and active participation of psychiatrists and psychologists in dedicated multidisciplinary teams. Therefore, it seems crucial for them to improve knowledge about specific difficulties and needs of these patients. The aim of this article is to report in a synthesizing manner the recent works evaluating the mental health and psychological status of individuals with DSDs.

Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep.

Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns. Dehydroepiandrosterone (DHEA) represents a new pharmacological agent with vascular effects, including improvement of PPHN in several animal models. We hypothesized that DHEA could decrease pulmonary vascular resistance (PVR) in the pulmonary circulation of fetal sheep.

Atomic-scale study of stacking faults in Zr hydrides and implications on hydride formation.

We performed atomic-scale ab initio calculations to investigate the stacking fault (SF) properties of the metastable ζ-ZrH zirconium hydride. The effect of H near the SF was found to entail the existence of negative SF energies, showing that the ζ compound is probably unstable with respect to shearing in the basal plane. The effect of temperature on SFs was investigated by means of free energy calculations in the quasiharmonic approximation.

The effect of metabolic syndrome on postoperative outcomes following laparoscopic colectomy.

Background: Among the criteria used to diagnose metabolic syndrome (MS), obesity and diabetes mellitus (DM) are associated with poor postoperative outcomes following colectomy. MS is also associated with colorectal cancer (CRC) and diverticulosis, both of which may be treated with colectomy. However, the effect of MS on postoperative outcomes following laparoscopic colectomy has yet to be clarified.

Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Fetal Pulmonary Circulation: An Experimental Study in Fetal Lambs.

Persistent pulmonary hypertension of the newborn (PPHN) causes significant morbidity and mortality in neonates. -3 Poly-unsaturated fatty acids have vasodilatory properties in the perinatal lung. We studied the circulatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fetal sheep and in fetal pulmonary arterial rings.

Interfacial properties of hydrides in α-Zr: a theoretical study.

In order to better understand hydride formation in zirconium alloys, heterophase interfaces between α-Zr and γ-ZrH are investigated by means of ab initio atomic-scale simulations of multilayers coupled with continuous elasticity. Our approach allows us to separate out the elastic contribution, leading to basal and prismatic [Formula: see text] interface energies around 200 [Formula: see text] and 750 [Formula: see text] respectively, i.e.

Contour scanning for penumbra improvement in pencil beam scanned proton therapy.

Proton therapy, especially in the form of pencil beam scanning (PBS), allows for the delivery of highly conformal dose distributions for complex tumor geometries. However, due to scattering of protons inside the patient, lateral dose gradients cannot be arbitrarily steep, which is of importance in cases with organs at risk (OARs) in close proximity to, or overlapping with, planning target volumes (PTVs). In the PBS approach, physical pencil beams are planned using a regular grid orthogonal to the beam direction.

SF1 and spleen development: new heterozygous mutation, literature review and consequences for NR5A1-mutated patient's management.

Steroidogenic factor 1 (encoded by SF1/NR5A1) is a transcription factor with multiple target genes involved in the development and function of multiple steroidogenic and non-steroidogenic tissues. NR5A1 mutations lead to several phenotypes, including sex reversal, spermatogenesis failure, premature ovarian failure and adrenocortical insufficiency. The implication of NR5A1 mutations in spleen development anomalies was recently highlighted.

Management of postoperative bleeding after laparoscopic left colectomy.

Background: Lower gastrointestinal bleeding after left colectomy is an uncommon complication that can lead to critical situation. Diagnostic and therapeutic manoeuvres should be performed in emergency with step-by-step strategy in order to avoid reoperation. This study aims to identify bleeding risks factors and describe a management strategy.

Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats.

Bronchopulmonary dysplasia (BPD) is one of the most common complications of prematurity, occurring in 30% of very low birth weight infants. The benefits of dietary intake of polyunsaturated fatty acids ω-3 (PUFA ω-3) during pregnancy or the perinatal period have been reported. The aim of this study was to assess the effects of maternal PUFA ω-3 supplementation on lung injuries in newborn rats exposed to prolonged hyperoxia.

Independent dose calculations for commissioning, quality assurance and dose reconstruction of PBS proton therapy.

Pencil beam scanning proton therapy allows the delivery of highly conformal dose distributions by delivering several thousand pencil beams. These beams have to be individually optimised and accurately delivered requiring a significant quality assurance workload. In this work we describe a toolkit for independent dose calculations developed at Paul Scherrer Institut which allows for dose reconstructions at several points in the treatment workflow.

Quality of life in adults with bladder exstrophy-epispadias complex.

Purpose: We evaluated quality of life in adults with bladder exstrophy-epispadias complex to improve patient and parent counseling.

Materials And Methods: We evaluated quality of life in a multicenter study using the SF-36® Medical Outcome Study questionnaire and a local questionnaire. A total of 47 patients born in 1957 to 1990 were followed due to bladder exstrophy-epispadias complex at the 4 participating hospitals.

[Prenatal diagnosis of hyperechogenic kidneys: A study of 17 cases].

Objectives: To evaluate the prenatal diagnosis and the prognostic value of ultrasound in case of fetal hyperechogenic kidneys.

Patients And Methods: Seventeen prenatally diagnosed cases of hyperechogenic kidneys were retrospectively reviewed at the University Hospital of Lille from 1997 to 2008. The clinical and ultrasound data were compared to the postnatal follow-up and the long-term prognosis.