[Experimental research on the antisecretory and antiulcer activity of (+/-) 15 alpha-OH-11-deoxyprostaglandin E1].

(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 was found to possess a pronounced antisecretory activity at stimulation of gastric secretion in cats with pentagastrin. In rats the compound exerted the protective effect of cells of the gastric mucosa, especially on indomethacin and stress models of ulcerogenesis. The cytoprotective effect of the compound seemed to be related to its action on secretion of mucus as well as to its stimulation of zinc accumulation in cells that stabilized cell membranes and suppressed the secretory activity of mast cells.

[Surgical aspects of formation of arteriovenous fistulas and experience with their use in chronic hemodialysis].

The authors report their experience with 71 procedures of constructing a subcutaneous arterio-venous fistula in 56 patients suffering chronic venous insufficiency. Surgical technic of 7 various modifications in producing arterio-venous fistulas on the upper and lower extremities is described and the methods of the postoperative management, as well. An analysis of main complications is given.